肺癌患者放疗前后血液TGF-β<sub>1</sub>变化与淋巴细胞亚群变化趋势相关性分析

doi:10.3760/cma.j.issn.1004-4221.2017.02.007

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Abstract Objective To investigate the relationship between the change in plasma level of transforming growth factor-beta1(TGF-β₁) after radiotherapy (RT) and short-term treatment outcomes in patients with lung cancer, and to analyze its relationship with the changes in lymphocyte subset percentages in peripheral blood. Methods In a prospective study, blood samples before, during, and after treatment were collected from 39 patients with lung cancer who were treated in our hospital from 2014 to 2016. Plasma level of TGF-β₁ was measured by enzyme-linked immunosorbent assay. The percentages of lymphocyte subsets in peripheral blood were determined at each time point. At one month after RT, chest computed tomography was performed to evaluate the short-term treatment outcomes. The response evaluation criteria in solid tumors were used to determine whether there was any response or not. Results Patients with lower plasma levels of TGF-β₁ after RT had significantly better short-term treatment outcomes (P<0.05). The changes in plasma level of TGF-β₁ after 2 and 4 weeks of RT and at the end of RT were correlated to the changes in the percentages of CD₄(+) T and CD₈(+) T cells and the CD₄(+)/CD₈(+) ratio at the same time point (r=-0.581,-0.516,-0.648, P<0.001;r=0.558, 0.545, 0.626, P<0.001;r=-0.615,-0.648,-0.598, P<0.001). Conclusions Lung cancer patients with reduced TGF-β₁ levels after RT have better treatment outcomes than those without decreases in TGF-β₁ levels after RT. The mechanism may be related to anti-tumor immunity.

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	Articles by authors
	Luo Jing
	Wei Tingting
	Xu Kunpeng
	Xu Liming
	Gong Linlin
	Ren Kai
	Wang Xin
	Zhao Lujun

Key words： Transforming growth factor Lymphocytes Lung neoplasms/radiotherapy
Fund program:National Natural Science Foundation of China (81372429)

Received: 17 November 2016

Corresponding Authors: Zhao Lujun,Email:zhaolujun@tjmuch.com

Cite this article:

Luo Jing,Wei Tingting,Xu Kunpeng et al. A correlation analysis of the changes in plasma level of transforming growth factor beta1 and lymphocyte subset percentages after radiotherapy for patients with lung cancer[J]. Chinese Journal of Radiation Oncology, 2017, 26(2): 150-154.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.02.007 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I2/150

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