Abstract Small Animal Radiation Research Platform (SARRP) is a highly efficient platform specifically designed for research in the fields of radiation oncology and radiobiology. This platform possesses precise radiometers with gantries capable of isocentric, coplanar, and non-coplanar conformal irradiation. Based on the three-dimensional images acquired by the cone-beam computed tomography, the platform can perform “real time” treatment planning and irradiation, which assures timeliness for precise irradiation and research on small animals. The wide application of SARRP not only accelerates the bench to bedside translation, but also facilitates the development of radiation oncology and radiobiology.
Corresponding Authors:
Deng Yun,Email:shiny_deng@126.com
Cite this article:
Zhang Yanjun,Deng Yun,Xu Qing et al. Application of small animal radiation research platform in radiotherapy[J]. Chinese Journal of Radiation Oncology, 2017, 26(2): 247-249.
Zhang Yanjun,Deng Yun,Xu Qing et al. Application of small animal radiation research platform in radiotherapy[J]. Chinese Journal of Radiation Oncology, 2017, 26(2): 247-249.
[1] Wong J,Armour E,Kazanzides P,et al. High-resolution,small animal radiation research platform with X-ray tomographic guidance capabilities[J].Int J Radiat Oncol Biol Phys,2008,71(5):1591-1599.DOI:10.1016/j.ijrobp.2008.04.025. [2] Tryggestad E,Armour M,Iordachita I,et al. A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform[J].Phys Med Biol,2009,54(17):5341-5357.DOI:10.1088/0031-9155/54/17/017. [3] Sayler E,Dolney D,Avery S,et al. Shielding considerations for the small animal radiation research platform (SARRP)[J].Health Phys,2013,104(5):471-480.DOI:10.1097/HP.0b013e318284f461. [4] Armour M,Ford E,Iordachita I,et al. CT guidance is needed to achieve reproducible positioning of the mouse head for repeat precision cranial irradiation[J].Radiat Res,2010,173(1):119-123.DOI:10.1667/RR1845.1. [5] Matinfar M,Iordachita I,Wong J,et al. Robotic delivery of complex radiation volumes for small animal research[A]//Proceedings of 2010 IEEE international conference on robotics and automation[C].Anchorage,Alaska:IEEE,2010:2056-2061.DOI:10.1109/ROBOT.2010.5509898. [6] Deng H,Kennedy CW,Armour E,et al. The small-animal radiation research platform (SARRP):dosimetry of a focused lens system[J].Phys Med Biol,2007,52(10):2729-2740.DOI:10.1088/0031-9155/52/10/007. [7] Matinfar M,Gray O,Iordachita I,et al. Small animal radiation research platform:imaging,mechanics,control and calibration[A]//Ayache N,Ourselin S,Maeder A.Medical image computing and computer-assisted intervention–MICCAI 2007[M].Berlin Heidelberg:Springer,2007:926-934.DOI:10.1007/978-3-540-75759-7_112. [8] Bolcaen J,Descamps B,Deblaere K,et al. MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP)[J].J Neuro-Oncol,2014,120(2):257-266.DOI:10.1007/s11060-014-1552-9. [9] Sharabi AB,Nirschl CJ,Kochel CM,et al. Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen[J].Cancer Immunol Res,2015,3(4):345-355.DOI:10.1158/2326-6066.CIR-14-0196. [10] Tuli R,Armour M,Surmak A,et al. Accuracy of off-line bioluminescence imaging to localize targets in preclinical radiation research[J].Radiat Res,2013,179(4):416-421.DOI:10.1667/RR2999.2. [11] Eslami S,Yang Y,Wong J,et al. An integrated X-ray/optical tomography system for pre-clinical radiation research[A]//Proceedings of the SPIE 8668,medical imaging 2013:physics of medical imaging[C].Lake Buena Vista (Orlando Area),Florida,USA:SPIE,2013,8668:866830.DOI:10.1117/12.2008060.