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Chinese Journal of Radiation Oncology  2016, Vol. 25 Issue (8): 867-871    DOI: 10.3760/cma.j.issn.1004-4221.2016.08.017
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Intraoperative radiotherapy using low-energy X rays:dosimetric characteristics and potential limitations in clinical application
Ouyang Bin,Xiao Zhenhua,Wang Zhenyu,Huang Botian,Wen Bixiu
Department of Radiation Oncology,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China
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Abstract  Objective To test intraoperative radiotherapy with mobile photon beam using the INTRABEAM system (Germany), and to analyze the dosimetric characteristics of low-energy photon beam using X-ray source and spherical applicators and explore its potential limitations in clinical application. Methods A special water phantom, a parallel-plate ionization chamber, and an electrometer were used to measure the depth dose rates and isotropy of dose distribution in x/y plane of X-ray source and different spherical applicators in the INTRABEAM system. Those data were then compared with the system data. Results For the X-ray source, the deviation of observed depth dose rate and isotropy in the x/y plane from the system data were-2.16%±1.36% and-1.9%~2.1%, respectively. For applicators with different diameters, the deviation of observed depth dose rate, transfer coefficient, and isotropy in x/y plane from the system data were-10.0%~2.3%,-8.9%~4.2%, and-1.6%~2.6%, respectively. Surface dose rate and dose gradient became larger with the decrease in the diameter of the spherical applicator. The measurement of depth dose rate and isotropy of X-ray source and spherical applicators showed good repeatability. The influencing factors for measurement accuracy included the positioning error of ionization chamber, energy response, noise current, and correction factor f’(R). Conclusions This study reveals the dosimetric characteristics of the INTRABEAM system, verifies the accuracy of the system data, and obtains the data for clinical application and routine quality assurance. However, large dose gradient and small therapeutic range may limit its wide clinical application.
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Articles by authors
Ouyang Bin
Xiao Zhenhua
Wang Zhenyu
Huang Botian
Wen Bixiu
Key wordsIntra-operative radiotherapy      Low energy photon      Dosimetry      Isotropy      Limitation     
    
Corresponding Authors: Wen Bixiu,Email:wenbix@mail.sysu.edu.cn     E-mail: wenbix@mail.sysu.edu.cn
Cite this article:   
Ouyang Bin,Xiao Zhenhua,Wang Zhenyu et al. Intraoperative radiotherapy using low-energy X rays:dosimetric characteristics and potential limitations in clinical application[J]. Chinese Journal of Radiation Oncology, 2016, 25(8): 867-871.
Ouyang Bin,Xiao Zhenhua,Wang Zhenyu et al. Intraoperative radiotherapy using low-energy X rays:dosimetric characteristics and potential limitations in clinical application[J]. Chinese Journal of Radiation Oncology, 2016, 25(8): 867-871.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.08.017     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I8/867
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