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Chinese Journal of Radiation Oncology  2016, Vol. 25 Issue (5): 462-466    DOI: 10.3760/cma.j.issn.1004-4221.2016.05.009
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Relationship of expression of APAF-1 and COX-2 with pathologic complete response to neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma
Peng Haihua,Yu Xin,Xi Shaoyan,Zhang Tian,Dong Jun,You Kaiyun,Cai Muyan,Wang Chengtao,Zhang Huizhong,Wen Bixiu,Gao Yuanhong
Department of Radiation Oncology,First Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510080,China (Peng HH,Zhang T,Dong J,Wang CT,Wen BX);Department of Radiation Oncology (Yu X,You KY,Gao YH), Department of Pathology (Xi SHY,Cai MY,Zhang HZH),Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Guangzhou 510060,China;Department of Radiation Oncology,Cancer Center of Guangzhou Medical University,Guangzhou 510075,China (Peng HH)
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Abstract   Objective To investigate the relationship of expression of apoptosis protease-activating factor 1(APAF-1) and cyclooxygenase-2(COX-2) with pathologic complete response (pCR) to neoadjuvant chemoradiotherapy (neo-CRT) for locally advanced rectal adenocarcinoma. Methods Paraffin-embedded tumor tissue sections were collected from 82 patients with locally advanced rectal adenocarcinoma who received neo-CRT and radical surgery from 2005 to 2012. Immunohistochemical assay was used to determine the expression of APAF-1 and COX-2. Postoperative pathological tissue sections were reassessed for evaluation of tumor regression grade (0-4, pCR=4) after radiochemotherapy. The relationship of expression of APAF-1 and COX-2 with pCR was analyzed by chi-square test or Fisher′s exact test. Logistic regression analysis was used to predict the influencing factors for pCR. Results The numbers of patients with grade 0, 1, 2, 3, and 4 tumor regression were 0, 6(7%), 33(40%), 20(24%), and 23(28%), respectively. Patients with high expression of APAF-1 had a significantly higher incidence of pCR than those with low expression of APAF-1(37% vs. 17%, P=0.047), while patients with low expression of COX-2 had a significantly higher incidence of pCR than those with high expression of COX-2(38% vs. 15%, P=0.028). Patients with high expression of APAF-1 and low expression of COX-2 had a significantly higher incidence of pCR than patients with high expression of APAF-1 and COX-2, patients with low expression of APAF-1 and COX-2, and patients with low expression of APAF-1 and high expression of COX-2(56% vs. 14%;56% vs. 17%;56% vs. 15%;P=0.005). The expression of APAF-1 was positively correlated with pCR (P=0.042), while the expression of COX-2 was negatively correlated with pCR (P=0.024). ConclusionsThe expression of APAF-1 and COX-2 is correlated with pCR to neo-CRT for locally advanced rectal adenocarcinoma. The measurement of expression of both APAF-1 and COX-2 holds promise for prediction of pCR.
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Key words Apoptosis protease-activating factor 1      Cyclooxygenase-2      Rectal neoplasms      Neoadjuvnt chemoradiotherapy      Complete pathological response      Apoptosis protease-activating factor 1      Cyclooxygenase-2      Rectal neoplasms      Neoadjuvnt chemoradiotherapy      Complete pathological response     
Received: 16 March 2015     
Corresponding Authors: Wen Bixiu,Email:wenbix@mail.sysu.edu.cn;Gao Yuanhong,Email: gaoyh@sysucc.org.cn   
Cite this article:   
. Relationship of expression of APAF-1 and COX-2 with pathologic complete response to neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(5): 462-466.
. Relationship of expression of APAF-1 and COX-2 with pathologic complete response to neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(5): 462-466.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.05.009     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I5/462
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