疗前FDG PET-CT代谢参数与食管癌放疗预后关系初步研究

doi:10.3760/cma.j.issn.1004-4221.2016.05.007

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Abstract Objective To investigate the prognostic value of metabolic parameters, maximum standard uptake value (SUV_max), metabolic tumour volume (MTV), total lesion glycolysis (TLG), and PET tumor length(PTL), in primary lesions of esophageal cancer on FDG PET-CT imaging in patients receiving radiotherapy or combined radiotherapy. Methods A total of 55 patients with stage Ⅰ-IV esophageal cancer who received PET-CT radiotherapy localization in our hospital from 2006 to 2012 were enrolled. The association of sex, age, primary lesion, TNM stage, SUV_max, MTV, TLG, PTL, and therapeutic methods with the patient’s prognosis was analyzed. The receiver operating characteristic curve was used to determine the cut-off values of SUV_max, MTV, TLG, and PTL, and the patients were divided into higher-value group and lower-value group. The Kaplan-Meier method was used to calculate survival rates, and the log-rank test was used for survival difference analysis. Results The median overall survival (OS) time for all patients was 19.1 months (95%CI 8.1-30.1), and the 1-, 2-, 3-, and 4-year OS rates were 59%, 45%, 35%, and 26%, respectively. The group with lower values of SUV_max(<11.4), MTV (<8.27cm³), TLG (<35.21), and PTL (<5.8 cm) had better prognosis than those with higher values (P=0.002, 0.021, 0.044, and 0.000).Conclusions SUV_max, MTV, TLG, and PTL before treatment have certain values in predicting the prognosis of patients with esophageal cancer. Risk stratification can be performed for these patients before radiotherapy according to these parameters, in order to develop individualized treatment regimens and improve prognosis.

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	Articles by authors
	Xie Yanting
	Zheng Rong
	Wu Ning
	Zhang Wenjie
	Liang Ying
	Liu Ying
	Li Xiaomeng
	Liang Meng
	Xiao Zefen
	Zhou Zongmei
	Feng Qinfu
	Wang Lyuhua
	Li Yexiong

Key words： Tomography,positron-emission Fluorodeoxyglucose Tomography,X-ray computed Esophageal neoplasms/radiotherapy Prognosis

Received: 26 March 2015

Corresponding Authors: Zheng Rong,Email:zrong99@163.com

Cite this article:

Xie Yanting,Zheng Rong,Wu Ning et al. Prognostic value of FDG PET-CT metabolic parameters before treatment in patients with esophageal cancer receiving radiotherapy[J]. Chinese Journal of Radiation Oncology, 2016, 25(5): 452-456.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.05.007 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I5/452

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