低钠血症与SCLC患者预后关系研究

doi:10.3760/cma.j.issn.1004-4221.2016.02.009

Abstract
Figure/Table
References()
Related Citation (15)
Read Tracking
Download Tracking

Download: PDF (369 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS) Supporting Info

Abstract Objective To investigate the association between hyponatremia and the prognosis of patients with small cell lung cancer (SCLC). Methods The clinical data of 489 patients with SCLC who were treated in Zhejiang Cancer Hospital from January 1, 2010 to December 31, 2012 were retrospectively analyzed.110 patients have hyponatremia in all patients.Hyponatremia incidence was compared with χ² test. Survival rates were calculated by the Kaplan-Meier method and compared by the log-rank test. The Coxproportional hazards model was applied to analyze the prognostic factors including hyponatremia. ResultsBefore initial treatment, after 2 cycles of chemotherapy, after radiotherapy, and after the end of the last treatment, the incidence of hyponatremia was 17.9%, 13.3%, 12.5%, and 18.9%, respectively;the 3-years survival rate were 10.1% vs. 21.1%(P=0.000),14.7% vs. 20.5%(P=0.022),12.1% vs. 28.3%(P=0.000),7.0% vs. 21.8%(P=0.000) with hyponatremia than normal blood sodium, respectively. The Cox regression analysis showed that the relative risk of death in patients with hyponatremia was elevated 1.297 times (95%CI=1.160-1.449, P=0.000), 1.366 times (95%CI=1.023-1.825,P=0.035), 1.770 times (95%CI=1.168-2.682,P=0.007), and 1.507 times (95%CI=1.167-1.944,P=0.002) in before initial treatment, after 2 cycles of chemotherapy, after radiotherapy, and after the end of the last treatment. Conclusion Hyponatremia is an independent prognostic factor for patients with SCLC.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Kong Yue
	Xu Yujin
	Tang Huarong
	Wang Jin
	Hu Xiao
	Ma Honglian
	Yu Bingqi
	Chen Jianxiang
	Zheng Yuanda
	Wang Shengye
	Chen Ming

Key words： Hyponatremia Carcinoma,small cell lung/chemotherapy Carcinoma,small cell lung/radiotherapy Prognosis
Fund program:National Natural Science Foundation of China (81402540)

Received: 06 January 2015

Corresponding Authors: Chen Ming,Email:chenming@zjcc.org.cn

Cite this article:

Kong Yue,Xu Yujin,Tang Huarong et al. Association between hyponatremia and prognosis of patients with small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2016, 25(2): 126-130.

URL:

http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.02.009 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I2/126

[1]Jackman DM.Johnson BE.Small-cell lung cancer[J].Lancet,2005,366(9494):1385-1396.DOI:10.1016/S0140-6736(05)67569-1.
[2]Campling BG.Sarda IR.Baer KA.et al. Secretion of atrial natriuretic peptide and vasopressin by small cell lung cancer[J].Cancer,1995,75(10):2442-2451.DOI:10.1002/1097-0142(19950515)75:10<2442::AID-CNCR2820751009>3.0.CO;2-Q.
[3]谢红滨.以肺外表现为首发症状的肺癌39例分析[J].中国医疗前沿,2011,6(10):57-58.DOI:10.3969/j.issn.1673-5552.2011.10.0038.Xie HB.Analysis of 39 cases of lung cancer With extrapulmonary manifestation as the first symptom[J].NaT Med Front Chin,2011,6(10):57-58.DOI:10.3969/j.issn.1673-5552.2011.10.0038.
[4]王娜平,张潇.以低钠血症为首发表现的肺癌5例临床分析[J].中国医学创新,2011,8(2):141-142.DOI:10.3969/j.issn.1674-4985.2011.02.083.
Wang NP,Zhang X.Clinical analysis of 5 cases of lung cancer as first manifestation of hyponatremia[J].Med Innov Chin,2011,8(2):141-142.DOI:10.3969/j.issn.1674-4985.2011.02.083.
[5]赵展光,宋世辉,张鹏.小细胞肺癌合并低钠血症的临床分析[J].天津医科大学学报,2011,17(2):222-223,242.DOI:10.3969/j.issn.1006-8147.2011.02.024.
Zhao ZG,Song SH,Zhang P.Clinical analysis of small cell lung cancer with the hyponatremia[J].J Tianjin Med Univ,2011,17(2):222-223,242.DOI:10.3969/j.issn.1006-8147.2011.02.024.
[6]朱晶,马丽霞,王胜,等.小细胞肺癌并发低钠血症的临床特点并12例临床分析[J].吉林医学,2011,32(25):5311-5312.DOI:10.3969/j.issn.1004-0412.2011.25.083.
Zhu P,Ma LX,Wang SH,et al. Clinical characteristics and clinical analysis of 12 patients with small cell lung cancer complicated with hyponatremia[J].Jilin Med J,2011,32(25):5311-5312.DOI:10.3969/j.issn.1004-0412.2011.25.083.
[7]Hansen O,Srensen P,Hansen KH.The occurrence of hyponatremia in SCLC and the influence on prognosis:a retrospective study of 453 patients treated in a single institution in a 10-year period[J].Lung Cancer,2010,68(1):111-114.DOI:10.1016/J.LUNGCAN.2009.05.015.
[8]Hermes A,Waschki B,Reck M.Hyponatremia as prognostic factor in small cell lung cancer-a retrospective single institution analysis[J].Respir Med,2012,106(6):900-904.DOI:10.1016/j.rmed.2012.02.010.
[9]马芳,刘先领,胡春宏,等.小细胞肺癌合并低钠血症的临床特点及预后分析[J].中南大学学报(医学版),2011,36(1):64-67.DOI:10.3969/j.issn.1672-7347.2011.01.010.
Ma F,Liu XL,Hu CH,et al. Clinical features and prognosis analysis of small-cell lung cancer complicated with hyponatremia[J].J Cent South Uni (Med Sci),2011,36(1):64-67.DOI:10.3969/j.issn.1672-7347.2011.01.010.
[10]Cerny T,Anderson H,Bramwell V,et al. Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients[J].Int J Cancer,1987,39(2):146-149.DOI:10.1002/ijc.2910390204.
[11]sterlind K,Andersen PK.Prognostic factors in small cell lung cancer:multivariate model based on 778 patients treated with chemotherapy with or without irradiation[J].Cancer Res,1986,46(8):4189-4194.DOI:10.1016/S0169-5002(87)80466-X.
[12]Sagman U,Maki E,Evans WK,et al. Small-cell carcinoma of the lung:derivation of a prognostic staging system[J].J Clin Oncol,1991,9(9):1639-1649.
[13]Umemura S,Segawa Y,Ueoka H,et al. Serum level of arginine-vasopressin influences the prognosis of extensive-disease small-cell lung cancer[J].J Cancer Res Clin Oncol,2007,133(8):519-524.DOI:10.1007/s00432-007-0196-y.
[14]Spasovski G,Vanholder R,Allolio B,et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia[J].Intensive Care Med,2014,40(3):320-331.DOI:10.1007/s00134-014-3210-2.
[15]Zumsteg MM,Casperson DS.Paraneoplastic syndromes in metastatic disease[J].Semin Oncol Nurs,1998,14(3):220-229.DOI:10.1016/S0749-2081(98)80031-4.
[16]Tang CSW,Howe T.Unusual presentations of malignancy[J].Medicine,2011,40(1):34-39.DOI:10.1016/j.mpmed.2011.09.003.
[17]Pranzatelli MR.Paraneoplastic syndromes:an unsolved murder[J].Semin Pediatr Neurol,2000,7(2):118-130.DOI:10.1053/pb.2000.6695.
[18]Rodrigues B,Staff I,Fortunato G,et al. Hyponatremia in the prognosis of acute ischemic stroke[J].J Stroke Cerebrovasc Dis,2014,23(5):850-854.DOI:10.1016/j.jstrokecerebrovasdis.2013.07.011.
[19]Rabinovitz A,Raiszadeh F,Zolty R.Association of hyponatremia and outcomes in pulmonary hypertension[J].J Card Fail,2013,19(8):550-556.DOI:10.1016/j.cardfail.2013.05.014.
[20]Olsson K, hlin B,Melander O.Epidemiology and characteristics of hyponatremia in the emergency department[J].Eur J Intern Med,2013,24(2):110-116.DOI:10.1016/j.ejim.2012.10.014.
[21]Kasi PM.Proposing the use of hyponatremia as a marker to help identify high risk individuals for lung cancer[J].Med Hypotheses,2012,79(3):327-328.DOI:10.1016/j.mehy.2012.05.023.