局部晚期宫颈癌腔内联合组织间插植3D-IGBT的剂量学研究

doi:10.3760/cma.j.issn.1004-4221.2015.03.009

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Abstract Objective To explore the dosimetric advantages of computed tomography-based and ultrasound-guided three-dimensional image-quided brachytherapy (3D-IGBT) combined with intracavitary/interstitial (IC/IS) brachytherapy for locally advanced cervical cancer. Methods A total of 45 patients with FIGO (2009) stage I_B2-IV_A locally advanced cervical cancer who received radical external beam radiotherapy and 3D-IGBT combined with IC/IS brachytherapy in our hospital from 2013 to 2014 were analyzed. After the treatment with ¹⁹²Ir-based IC/IS brachytherapy, patients had needles removed from the original images and received treatment only from IC radiation sources. Dosimetric differences in the planning D₉₀ for high-risk clinical target volume (HR-CTV), D₉₀ for intermediate-risk CTV (IR-CTV), and D_{2 cm³} for the bladder, rectum, sigmoid colon, and small intestines were determined and analyzed by paired t-test. Results A total of 260 after-loading treatment plans, including IC/IS treatment plans for 130 patients and IC treatment plans for 130 patients, were made. The D₉₀ for HR-CTV and D₉₀ for IR-CTV in the IC/IS brachytherapy group were significantly higher than those in the IC brachytherapy group (P=0.000;P=0.000). Moreover, the average D_{2 cm³} values for the bladder and rectum were significantly reduced in the IC/IS brachytherapy group compared with those in the IC brachytherapy group (P=0.000;P=0.006). Conclusions The 3D-IGBT combined with IC/IS brachytherapy not only achieves a higher dose for the target volume, but also reduces the radiation dose to the bladder and rectum in the treatment of locally advanced cervical cancer.

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	Zhang Ning^*
	Zhao Zhipeng
	Cheng Guanghui
	He Mingyuan
	Zhao Hongfu
	Ge Yuping

Key words： Cervicalneoplasms/three-dimensional brachytherapy Intracavitary Interstitial Dosimetry

Corresponding Authors: Cheng Guanghui, Email:chengguanghuifl@163.com

Cite this article:

Zhang Ning^*,Zhao Zhipeng,Cheng Guanghui et al. Dosimetric study of three-dimensional image-quided brachytherapy combined with intracavitary/interstitial brachytherapy in locally advanced cervical cancer[J]. Chinese Journal of Radiation Oncology, 2015, 24(3): 267-270.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2015.03.009 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2015/V24/I3/267

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