[1] Jenkins P,Watts J. An improved model for predicting radiation pneumonitis incorporating clinical and dosimetric variables[J]. Int J Radiat Oncol Biol Phys,2011,80:1023-1029. [2] Wu Z,Wang X,Yang R,et al. Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice[J]. Exp Ther Med,2013,5:771-776. [3] Zhao L,Sheldon K,Chen M,et al. The predictive role of plasma TGF-beta 1 during radiation therapy for radiation-induced lung toxicity deserves further study in patients with non-small cell lung cancer[J]. Lung Cancer,2008,59:232-239. [4] Rube CE,Wilfert F,Palm J. Irradiation induces a biphasic expression of pro-inflammatory cytokines in the lung[J]. Strahlenther Onkol,2004,180:442-448. [5] Anscher MS,Thrasher B,Zgonjainn L,et al. Smallmolecular inhibitor of transforming growth factor beta protects against development of radiationinduced lung injury[J]. Int J Radiat Oncol Biol Phys,2008,71:829-837. [6] Monceau V,Pasinetti N,Schupp C,et al. Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity[J]. Curr Drug Targets,2010,11:1395-1404. [7] Flechsig P,Dadrich M,Bickelhaupt S,et al. LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals[J]. Clin Cancer Res,2012,18:3616-3627. [8] Mahmood J,Jelveh S,Calveley V,et al. Mitigation of radiation-induced lung injury by Genistein and EUK-207[J]. Int J Radiat Biol,2011,87:889-901. [9] Chen Y,Hyrien O,Williams J,et al. Interleukin(IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis[J]. Int J Radiat Oncol Biol Phys,2005,62:260-266. [10] Rübe CE,Palm J,Erren M,et al. Cytokine plasma levels: reliable predictors for radiation pneumonitis[J/OL]? PloS One,2008,3:e2898[2013-10-12].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483418/. [11] Ogata T,Yamazaki H,Teshima T,et al. Early administration of IL-6RA does not prevent radiation induced lung injury in mice[J/OL]. Radiat Oncol,2010,5:26[2013-10-12].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864283/. [12] Mazeron R,Etienne-Mastroianni B,Pérol D,et al. Predictive factors of late radiation fibrosis: a prospective study in non-small cell lung cancer[J]. Int J Radiat Oncol Biol Phys,2010,77:38-43. [13] Meng Y,Beckett MA,Liang H,et al. Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy[J]. Cancer Res,2010,70:1534-1543. [14] Hill RP,Zaidi A,Mahmood J,et al. Investigations into the role of inflammation in normal tissue response to irradiation[J]. Radiother Oncol,2011,101:73-79. [15] Rhaleb NE,Pokharel S,Sharma UC,et al. N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1 β-mediated matrix metalloproteinase activation in cardiac fibroblasts[J]. Pflugers Arch,2013,465:1487-1495. [16] Cai Y,Zhu L,Zhang F,et al. Non-Invasive Monitoring of Pulmonary Fibrosis by Targeting Matrix Metalloproteinases(MMPs)[J]. Mol Pharm,2013,10:2237-2247. [17] 刘欣,王炳胜,刘秀芳.放射性肺损伤大鼠的数字化基因表达谱分析[J].解放军医药杂志,2013,25:14-17. [18] Lee WH,Warrington JP,Sonntag WE,et al. Irradiation alters MMP-2/TIMP-2 system and collagen type Ⅳ degradation in brain[J]. Int J Radiat Oncol Biol Phys,2012,82:1559-1566. [19] Zhou Y,Xia L,He ZS,et al. Modulation of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in RAW264.7 cells by irradiation[J]. Mol Med Rep,2010,3:809-813. [20] Susskind H,Hymowitz MH,Lau YH,et al. Inereased Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung and breast cancer are altered during chest radiotherapy[J]. Int J Radiat Oncol Biol Phys,2003,56:1161-1169. [21] Manetti M,Guiducci S,Romano E,et al. Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage[J]. Ann Rheum Dis,2012,71:1064-1072. [22] 李新春,宋良文,杨蕾蕾,等.MMP-12异常表达对放射性肺损伤大鼠肺内成纤维细胞转化的影响[J].解放军医学杂志,2009,34:267-270. [23] Strup-Perrot C,Vozenin-Brotons MC,Vandamme M,et al. Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells[J]. World J Gastroenterol,2005,11:6312-6321. [24] Yang K,Palm J,Knig J,et al. Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury[J]. Int J Radiat Biol,2007,83:665-676. [25] Ma B,Zhou PY,Ni W,et al. Inhibition of activin receptor-like kinase 5 induce matrix metallopeptidase 9 expression and aggravates lipopolysaccharide-induced pulmonary injury in mice[J]. Eur Rev Med Pharmacol Sci,2013,17:1051-1059. [26] Zhang L,Yang M,Bi N,et al. ATM polymorphisms are associated with risk of radiation-induced pneumonitis[J]. Int J Radiat Oncol Biol Phys,2010,77:1360-1368. [27] Xiong H,Liao Z,Liu Z,et al. ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy[J]. Int J Radiat Oncol Biol Phys,2013,85:1066-1073. [28] Yang M,Zhang L,Bi N,et al. Association of p53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy[J]. Int J Radiat Oncol Biol Phys,2011,79:1402-1407. [29] Yuan X,Liao Z,Liu Z,et al. Single nucleotide polymorphism at rs1982073: T869C of the TGFβ1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy[J]. J Clin Oncol,2009,27:3370-3378. [30] Wang L,Bi N. TGF-beta1 gene polymorphisms for anticipating radiation-induced pneumonitis in non-small-cell lung cancer: different ethnic association[J]. J Clin Oncol,2010,28:621-622. [31] Voets AM,Oberije C,Struijk RB,et al. No association between TGF-β1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients[J]. Radiother Oncol,2012,105:296-298. [32] Molthen RC,Wu Q,Fish BL,et al. Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril[J]. Respirology,2012,17:1261-1268. [33] Kma L,Gao F,Fish BL,et al. Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax[J]. J Radiat Res,2012,53:10-17. [34] Cappuccini F,Eldh T,Bruder D,et al. New insights into the molecular pathology of radiation-induced pneumopathy[J]. Radiother Oncol,2011,101:86-92. [35] Brickey WJ,Neuringer IP,Walton W,et al. MyD88 provides a protective role in long-term radiation-induced lung injury[J]. Int J Radiat Biol,2012,88:335-347.