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Status of breast conservative therapy for breast cancer in China between 1999 and 2008:an epidemiological study
WANG Shu-lian*, LI Ye-xiong, ZHANG Bao-ning, SONG Qing-kun, LI Jing, FAN Jin-hu, ZHANG Bin, YANG Hong-jian, XIE Xiao-ming, TANG Zhong-hua, LI Hui, LI Jia-yuan, HE Jian-jun, QIAO You-lin.*
Department of Radiation Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
Abstract Objective To investigate the status of breast conservative therapy for breast cancer in Mainland China. Methods A multi-center retrospective epidemiological study was undertaken. Patients with breast cancer treated between 1999 and 2008 were randomly selected from seven hospitals. 230 patients treated with breast conservative therapy were included for this analysis. Information on patients′ characteristics, pathology and treatment were collected and analyzed. The use of postoperative radiotherapy (RT) and radiation targets were analyzed. Wilcoxon analysis, Cochran-Armitage trend test and the chi-square test were used to compare differences. Results The median age of the patients was 43 years (range, 23—85). 198(86.1%) patients received axillary dissection, 16(7.0%) sentinel lymph node biopsy and 15(6.5%) patients didn′t have axillary operation,1(0.4%) unknown. Of 164(71.3%) patients who had frozen section analysis for intraoperative margin assessment, 17(10.4%) had positive margin and underwent 31 subsequent re-excision. One patient had positive margin on final analysis after surgery. 165(71.7%) patients received RT. From 1999 to 2008, there was no significant change in the use of RT (P=0.212). However, there were significant regional differences in the use of RT (P=0.000). 134(81.2%) patients received tumor bed boost after whole breast radiation. Of 152 patients with RT (excluding patients with ductal carcinoma in situ), 48(31.6%), 12(7.9%) and 8(5.3%) had received RT in supraclavicular fossa (SCF), axilla and internal mammary chain, respectively. The use of SCF RT was 31.5%(28/89), 54.2%(13/24) and 100%(7/7) for patients with 0, 1—3 and ≥4 positive axillary nodes (P=0.000).Conclusions The use of breast conservative surgery and sentinel node biopsy is quite low in the treatment of DOI:10.3760/cma.j.issn.1004-4221.2013.06.001 作者单位:100021 北京协和医学院中国医学科学院肿瘤医院肿瘤研究所放疗科(王淑莲、李晔雄),乳腺外科(张保宁),流行病室(宋清坤、李静、范金虎、乔友林);辽宁省肿瘤医院乳腺外科(张斌);浙江省肿瘤医院乳腺外科(杨红健);中山大学附属肿瘤医院乳腺科(谢小明);中南大学湘雅二院乳腺甲状腺外科(唐中华);四川省肿瘤医院乳腺外科(李卉);四川大学华西公共卫生学院流行病室(李佳圆);西安交通大学附属第一医院肿瘤外科(何建军) 通信作者:李晔雄,Email:yexiong@yahoo.comearly breast cancer patients in Mainland China. Radiotherapy after breast-conserving surgery ranges are relatively specification. The use of radiotherapy after breast conservative surgery needs improving.
Corresponding Authors:
LI Ye-xiong,Email:yexiong@yahoo.com
Cite this article:
WANG Shu-lian,LI Ye-xiong,ZHANG Bao-ning et al. Status of breast conservative therapy for breast cancer in China between 1999 and 2008:an epidemiological study[J]. Chinese Journal of Radiation Oncology, 2013, 22(6): 427-430.
WANG Shu-lian,LI Ye-xiong,ZHANG Bao-ning et al. Status of breast conservative therapy for breast cancer in China between 1999 and 2008:an epidemiological study[J]. Chinese Journal of Radiation Oncology, 2013, 22(6): 427-430.
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