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Nasopharyngeal carcinoma treated by intensity-modulated radiotherapy:long-term results of 416 patients
YI Jun-lin, GAO Li, HUANG Xiao-dong, LUO Jing-wei, Xiao Jian-ping, LI Su-yan, WANG Kai, ZHANG Shi-ping, QU Yuan, XU Guo-zhen
Department of Radiation Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021,China Corresponding author:Gao Li,Email:li_gao2008@yahoo.com.cn
Abstract Objective To summarize the long term outcomes and prognostic factors of nasopharyngeal carcinoma (NPC) treated by intensity-modulated radiotherapy. Methods From Nov 2001 to Dec 2009, totally 416 newly diagnosed NPC patients was treated in our hospital. The prescribed dose was 70－78 Gy to the gross tumor volume and 70 Gy to the positive neck nodes, 60 Gy to the clinical target volume, and 50－56 Gy to the clinically negative neck. Among 333 stage Ⅲ/Ⅳ patients according to the 2010 UICC staging system, 187 received concurrent chemoradiotherapy with a regimen of weekly cisplatin 30 mg/m2.Local control rate (LC), overall survival (OS), disease-free survival (DFS) and distant metastasis-free survival (DMFS) were estimated using the Kaplan-Meier method. Results The follow up rate is 98.0%.158 patients was followed up more than 5 years. The 5 years LC, OS, DFS and DMFS of whole group were 87.7%,82.1%,71.8% and 84.5%. Sex, Age, T stage and N stage were independent prognostic factors for OS (χ2=4.59,11.20,19.40,18.00, P=0.03,0.00,0.00,0.00), T and N stage were independent prognostic factors for DFS (χ2=33.50,21.20,P=0.00,0.00) and DMFS (χ2=11.90,14.60,P=0.01,0.01). The 5 years LC, OS, DFS and DMFS for local-regional advanced disease with or without concurrent chemotherapy was 82.2% and 90.7%(χ2=1.72,P=0.19),70.2% and 83.4%(χ2=1.42, P=0.23), 62.8% and 73.2%(χ2=2.83, P=0.09),78.0% and 83.2%(χ2=0.37,P=0.55) respectively. Conclusions The long term outcomes of nasopharyngeal carcinoma treated by intensity-modulated radiotherapy was encouraged. The role of concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma treated by intensity-modulated radiotherapy needs further investigated.
. Nasopharyngeal carcinoma treated by intensity-modulated radiotherapy:long-term results of 416 patients[J]. Chinese Journal of Radiation Oncology, 2012, 21(3): 196-200.
. Nasopharyngeal carcinoma treated by intensity-modulated radiotherapy:long-term results of 416 patients[J]. Chinese Journal of Radiation Oncology, 2012, 21(3): 196-200.
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