铁死亡在肿瘤放射生物学效应中的研究进展

doi:10.3760/cma.j.cn113030-20220516-00177

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Abstract Ferroptosis is a new form of regulated cell death discovered in recent years, which is iron-dependent cell death characterized by peroxidation of polyunsaturated fatty acid phospholipids. Recent studies have shown that radiotherapy can induce ferroptosis in cancer cells via ionizing radiation. Targeting ferroptosis plays a synergistic role in tumor suppression with radiation, which not only further deepens the connotation of radiobiology, but also provides a new perspective for tumor radiosensitization. This review systematically summarizes the occurrence and defense of ferroptosis, focusing on the key role of ferroptosis in the radiobiological effects of tumor cells and the potential application of ferroptosis in radiosensitization.

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	Articles by authors
	Wang Tianxiang
	Du Mingyu
	Zhang Pingchuan
	Yin Li
	He Xia

Key words： Ferroptosis Neoplasms malignant Radiobiology Radiation tolerance

Received: 16 May 2022

Corresponding Authors: Yin Li, Email: yinli_2012@126.com; He Xia, Email: hexia206@sina.com

Cite this article:

Wang Tianxiang,Du Mingyu,Zhang Pingchuan et al. Research progress on radiobiological effects of ferroptosis in cancer[J]. Chinese Journal of Radiation Oncology, 2023, 32(8): 743-747.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20220516-00177 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2023/V32/I8/743

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