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Research progress on the effect of hyperthermia on vascular endothelial growth factor in tumor microenvironment
Cong Yuan1,2, Shao Yun1,2, Zhou Xuexiao1,2, Shen Pei1,2, Wang Shengzhi2
1School of Stomatology of Qingdao University, Qingdao 266003, China; 2Department of Oral and Maxillofacial Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
Abstract Vascular endothelial growth factor (VEGF) plays an important role in promoting tumor vascular growth and changing vascular wall permeability. With the in-depth study of tumor hyperthermia and tumor microenvironment, more and more studies have shown that hyperthermia exerts multiple regulatory effects on VEGF in tumor microenvironment. Combined with current research progress in China and abroad, this article reviews the effect of hyperthermia on VEGF and its related cells and factors in tumor microenvironment, aiming to provide new ideas for the clinical application of tumor hyperthermia combined with immune or targeted therapy.
Fund:Yantai Science and Technology Plan Project (2022MSGY076)
Corresponding Authors:
Wang Shengzhi, Email: Wangsz916@163.com
Cite this article:
Cong Yuan,Shao Yun,Zhou Xuexiao et al. Research progress on the effect of hyperthermia on vascular endothelial growth factor in tumor microenvironment[J]. Chinese Journal of Radiation Oncology, 2023, 32(8): 737-742.
Cong Yuan,Shao Yun,Zhou Xuexiao et al. Research progress on the effect of hyperthermia on vascular endothelial growth factor in tumor microenvironment[J]. Chinese Journal of Radiation Oncology, 2023, 32(8): 737-742.
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2023, Vol. 32 
