宫颈癌术后放疗急性肠道不良反应与剂量‐体积参数相关性

doi:10.3760/cma.j.cn113030-20210928-00380

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Abstract Objective To identify dose‐volume parameters to predict the incidence of acute intestinal toxicity in cervical cancer patients after postoperative adjuvant radiotherapy. Methods Clinical data of 93 cervical cancer patients who underwent postoperative adjuvant intensity‐modulated radiotherapy (IMRT) were retrospectively evaluated. The dose‐volume parameters comprised the absolute volume of the bowel receiving 5‐45 Gy (5 Gy interval) radiation dose and the total volume of the bowel. The acute radiation-induced intestinal toxicity was evaluated by Radiation Therapy Oncology Group (RTOG) criteria. The association between the irradiated bowel volume and acute intestinal toxicity was analyzed. Results A total of 26 (28%) patients experienced grade ≥2 acute intestinal toxicity. A strong relationship between grade ≥2 acute intestinal toxicity and the irradiated small bowel volume was observed at the total volume of small bowel, small bowel V_{5 Gy}, V_{10 Gy} and V_{15 Gy} (all P<0.05). Small bowel V_{10 Gy} (HR=1.028, 95%CI, 0.993‐1.062, P=0.029) and small bowel V_{15 Gy}(HR=0.991, 95%CI, 0.969‐1.013, P=0.034)were the independent risk factors for evident acute intestinal toxicity. Conclusion Dose‐volume parameters of the small bowel can be used as predictors for the occurrence of grade ≥2 acute intestinal toxicity in cervical cancer patients undergoing postoperative adjuvant radiotherapy.

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	Xu Bichun
	Guo Qi
	Qian Jianjun
	Cai Shang
	Tian Ye

Key words： Uterine cervical neoplasms Radiotherapy intensity‐modulated Adverse reaction intestinal Dose‐volume parameters

Received: 28 September 2021

Fund:Jiangsu Key Project in Advanced Clinical Technique (BL2018657); Suzhou Project in Diagnosis and Treatment for Common Disease (LCZX202005); Medical Talent of Suzhou; Young Talent Support Project of the 2nd Affiliated Hospital of Soochow University(XKTJ-RC202007)

Corresponding Authors: Tian Ye, Email: dryetian@126.com

Cite this article:

Xu Bichun,Guo Qi,Qian Jianjun et al. Correlation between acute intestinal toxicity and dose-volume parameters in patients with cervical cancer receiving postoperative adjuvant radiotherapy[J]. Chinese Journal of Radiation Oncology, 2023, 32(3): 235-240.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20210928-00380 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2023/V32/I3/235

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