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Analysis of the rectum and bladder changes in prostate precise radiotherapy under the bowel and bladder preparation
Li Ting1,2, Guo Yujun1,2, Yang Xin1, Wu Manli1,3, He Mengxue1, Dai Xinyi1,2, Tian Yue1,2, Zhang Shujing1,2, Mai Xiuying1, He Liru1, Huang Sijuan1
1State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; 2Guangzhou Xinhua College,Guangzhou 510520,China; 3Department of Radiation Oncology, Anhui Wanbei Coal-Electricity Group General Hospital (The Third Affiliated Hospital of Bengbu Medical College), Suzhou 234000, China
AbstractObjective To analyze the clinically acceptable and reproducible bladder and rectum volumes of prostate cancer patients during radiotherapy under bladder and bowel preparation, aiming to provide quantitative indicators for bowel and bladder preparation before and after radiotherapy. Methods Clinical data of 275 prostate cancer patients with strict bladder and bowel preparation and completion of whole course radical radiotherapy at Sun Yat-sen University Cancer Center from April 2015 to December 2020 were retrospectively analyzed. Patients were scanned with cone beam CT (CBCT) before each treatment and the setup error was recorded. Sixty-six patients were selected by simple random sampling and the bladder and rectum on daily CBCT was outlined using MIM software. The relationship between the ratio of daily bladder or rectum volume to the planned bladder or rectum volume (relative value of volume) and setup error was analyzed. Quantitative data were expressed as mean±SD. Normally distributed data were analyzed by paired t-test while non-normally distributed data were assessed by Kruskal-Wallis test. Results The bladder and rectum volume on planning CT were (370.87±110.04) ml and (59.94±25.07) ml of 275 patients. The bladder and rectum volumes on planning CT were (357.51±107.38) ml and (65.28±35.37) ml respectively of the 66 selected patients with 1611 sets of CBCT images. And the bladder and rectum volumes on daily CBCT were (258.96±120.23) ml and (59.95 ± 30.40) ml. The bladder volume of patients was decreased by 3.59 ml per day on average during the treatment and 0.37 ml for the rectum volume. According to the bladder volume on planning CT, all patients were divided into three groups: <250 ml, 250-450 ml and >450 ml groups. The relative value of volume in the 250-450 ml group during the course of radiotherapy was the smallest. And the setup error in the superior and inferior (SI) direction was (0.28±0.24) cm and (0.19±0.17) cm in the left and right (LR) direction, significantly lower than those in the other two groups (both P≤0.027). According to the rectum volume on planning CT, all patients were divided into four groups: <50 ml, 50-<80 ml, 80-120 ml and >120 ml groups. The <50 ml group had the smallest relative value of volume during radiotherapy, and the setup error in the SI direction was (0.26±0.22) cm and (0.24±0.22) cm in the anterior and posterior (AP) direction, significantly smaller than those in the other groups (both P≤0.003). The setup errors in the SI, LR, AP directions of the enrolled 66 patients were (0.30±0.25) cm, (0.20±0.18) cm and (0.28±0.27) cm, respectively. Among them, the relative value of bladder volume in the AP direction was (0.73±0.37) in the setup error <0.3 cm group, which was statistically different from those in the setup error 0.3-0.5 cm and >0.5 cm groups (both P<0.05). Conclusion Under the bladder and bowel preparation before planning CT, the appropriate bladder and rectum volumes are in the range of 250-450 ml and <50 ml, which yields higher reproducibility and smaller setup error.
Fund:; Fund programs: Youth Innovation Project of Sun Yat-sen University Cancer Center (QNYCPY32); Basic and Applied Basic Research Foundation of Guangdong Province (2021A1515220140); National Natural Science Foundation of China (12075329); Innovation and Entrepreneurship Training Program for College Students (S202113902030)
Corresponding Authors:
He Liru, Email: helir@sysucc.org.cn; Huang Sijuan, Email: huangsj@sysucc.org.cn
Cite this article:
Li Ting,Guo Yujun,Yang Xin et al. Analysis of the rectum and bladder changes in prostate precise radiotherapy under the bowel and bladder preparation[J]. Chinese Journal of Radiation Oncology, 2023, 32(2): 124-130.
Li Ting,Guo Yujun,Yang Xin et al. Analysis of the rectum and bladder changes in prostate precise radiotherapy under the bowel and bladder preparation[J]. Chinese Journal of Radiation Oncology, 2023, 32(2): 124-130.
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