海马保护在全脑放疗中的研究进展

doi:10.3760/cma.j.cn113030-20211009-00388

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Abstract Whole brain radiotherapy (WBRT) is the standard radiotherapy regimen of preventive radiation for patients diagnosed with brain metastases and non-small cell lung cancer, which can improve intracranial control and prolong overall survival. However, neurocognitive functions (NCF) decline due to impaired hippocampal might occur thereafter. Recent studies have shown that hippocampal sparing WBRT (HS-WBRT) is capable of protecting neurocognitive function and improving quality of life (QOL). In this review, the authors described the methods and significance of hippocampal sparing, summarized the research progress on clinical trials related to HS-WBRT in combination with the development of radiotherapy technology and experimental drugs, and discussed the existing controversies and problems, aiming to provide reference for clinical work.

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	Articles by authors
	Gui Zhongxuan
	Han Tingting
	Wang Fan

Key words： Neoplasm metastasis, brain Whole-brain radiotherapy Neurocognitive function Hippocampal protection

Received: 09 October 2021

Corresponding Authors: Wang Fan, Email: wangfan1965@126.com

Cite this article:

Gui Zhongxuan,Han Tingting,Wang Fan. Recent advances in hippocampal sparing whole brain radiotherapy[J]. Chinese Journal of Radiation Oncology, 2023, 32(1): 55-59.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20211009-00388 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2023/V32/I1/55

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