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Efficacy and safety of intraoperative radiotherapy for pancreatic cancer: a meta-analysis
Cao Lei1, Yang Daxiong1, Zeng Lu1, Lin Lili1, Wang Huixia1, Duan Xiaoyu1, Li Xuxia1, Cai Hongyi1,2
1The First Clinical Medicine College of Gansu University of Chinese Medicine, Lanzhou 730000, China; 2Department of Radiotherapy, Gansu Provincial Hospital, Lanzhou 730000, China
AbstractObjective To compare and analyze the efficacy and safety of intraoperative radiotherapy (IORT) combined with conventional therapy (surgery combined with radiochemotherapy) and conventional therapy alone for pancreatic cancer. Methods Literature review was conducted from PubMed, Cochrane Library, Web of Science, Embase, Chongqing VIP, CNKI, Wanfang Data and China Biomedical Literature Service System (SinoMed). The literatures that met the inclusion criteria were screened and the data were extracted. Meta-analysis was carried out by RevMan 5.4 software. Results A total of 11 studies consisting of 813 patients were included. According to the combined results, compared with conventional therapy, IORT combined with conventional therapy could improve the overall survival rate of pancreatic cancer (HR=0.66, 95%CI=0.54-0.81, Z=4.03, P<0.001), and did not increase the treatment-related side effects (OR=1.00, 95%CI=0.69-1.46,Z=0.01, P=0.99), but failed to bring benefit to the local control rate (HR=0.56, 95%CI=0.31-1.01,Z=1.93, P=0.05). Conclusions The overall survival rate in the IORT combined with conventional therapy group is significantly better than that in the conventional therapy group. No significant difference is found in the treatment-related adverse reactions between two groups. IORT combined with conventional therapy is worthy of clinical application.
Corresponding Authors:
Cai Hongyi, Email: gschy333@163.com
Cite this article:
Cao Lei,Yang Daxiong,Zeng Lu et al. Efficacy and safety of intraoperative radiotherapy for pancreatic cancer: a meta-analysis[J]. Chinese Journal of Radiation Oncology, 2023, 32(1): 22-27.
Cao Lei,Yang Daxiong,Zeng Lu et al. Efficacy and safety of intraoperative radiotherapy for pancreatic cancer: a meta-analysis[J]. Chinese Journal of Radiation Oncology, 2023, 32(1): 22-27.
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