二甲双胍的放疗增敏机制及临床应用前景分析

doi:10.3760/cma.j.cn113030-20210408-00142

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Abstract Metformin is the basic drug for type 2 diabetes mellitus. More and more studies have shown that metformin has anti‐tumor effect, and its radiosensitization effect has been gradually found. Metformin can increase the radiosensitivity of tumor cells by improving hypoxia, increasing reactive oxygen species, inhibiting DNA damage repair, inducing cell cycle arrest and regulating immune microenvironment. However, several recently published randomized controlled trials have not confirmed that metformin can increase the efficacy of chemoradiotherapy. In this review, the mechanism and clinical results of metformin radiosensitization were summarized. The dose of metformin will be an important factor for basic and clinical research in the future.

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	Articles by authors
	Xiong Xin
	Fan Xingwen

Key words： Metformin Radiotherapy Radiosensitization

Received: 08 April 2021

Corresponding Authors: Fan Xingwen, Email: wenxingfan@126.com

Cite this article:

Xiong Xin,Fan Xingwen. Radiosensitization mechanism of metformin and analysis of clinical application prospect[J]. Chinese Journal of Radiation Oncology, 2022, 31(10): 966-970.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20210408-00142 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2022/V31/I10/966

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