结直肠癌脑转移瘤的单次SRS与多分次SRT治疗比较研究

doi:10.3760/cma.j.cn113030-20220207-00055

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Abstract Objective To compare the efficacy and side effects of multi-fraction stereotactic radiotherapy (SRT) and single-fraction stereotactic radiosurgery (SRS) in the treatment of brain metastases from colorectal cancer.Methods A total of 98 patients with brain metastases from colorectal cancer searched from the database of Professional Committee of Brain Metastasis of Shanghai Anticancer Association were recruited in this study. Among them, 46 patients weretreated with SRT and 52 patients with SRS. Clinical characteristics of all patients were analyzed between two groups and the local tumor control rate, median survival time and the incidence of radiation-induced brain injury were compared between two groups. Results The objective remission rates (ORR) in the SRT and SRS groups were 76.1% and 67.3%, respectively. The 12-month local tumor control rates were 88.3% and 83.9% between two groups, with no statistical difference (P=0.689). The median overall survival time of all patients was 11.6 months, 10.8 months in the SRT group and 12.7 months in the SRS group. There was no statistical difference between two groups (P=0.129). Multivariate analysis showed that the main factors leading to poor prognosis included the number of tumors of >3(P=0.026), low GPA score (P=0.035), and lack of systematic treatment mode and bevacizumab (P=0.001). There was no statistical difference in the incidence of acute and late radiation-induced brain injury between two groups. Conclusions Both SRT and SRS are effective therapies for brain metastases from colorectal cancer. The synergistic application of systematic treatment mode may be one of the main reasons affecting the survival time of the patients.

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	Articles by authors
	Pan Mianshun
	WangMeng
	Li Yong
	Wu Junlan
	Wang Peng
	Shao Xianjun
	Liang Xiaohua
	Zhang Feifei
	Shen Meihua

Key words： Colorectal neoplasms,brain metastasis Stereotactic radiotherapy Stereotactic radiosurgery

Received: 07 February 2022

Fund:Application demonstration of colorectal cancer intelligent diagnosis and treatment system (20DZ1100106)

Corresponding Authors: Shen Meihua, Email:littlelovehouse@126.com

Cite this article:

Pan Mianshun,WangMeng,Li Yong et al. Single-fraction SRS and multi-fraction SRT for brain metastases from colorectal cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(4): 347-351.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20220207-00055 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2022/V31/I4/347

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