低剂量4DCT扫描在肺内孤立性肿瘤模拟定位与靶区构建中的应用价值

doi:10.3760/cma.j.cn113030-20210122-00037

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Abstract Objective To explore the feasibility of low-dose 4DCT scanning in simulation and target delineation for solitary pulmonary tumors (SPTs). Methods 23 patients with SPTs received 4DCT scanning simulation with the conventional scanning (CON), low voltage (LV), low current (LA) and low voltage combined with low current (LVA) in sequence. Based on the 4DCT images derived from the four sets of scanning parameters, the internal gross tumor volume (IGTVCON, IGTVV, IGTVA, IGTVVA) of SPTs were delineated and matched. Taking IGTVCON as reference, the tumor displacement and the centroid position of IGTVV, IGTVA and IGTVVA were compared with IGTVCON. The radiation doses under different scanning parameters were compared. Results The volumes of IGTVCON, IGTVV and IGTVA were (12.26±12.30) cm³,(12.21±12.16) cm³ and (11.87±11.70) cm³, respectively (P=0.337). IGTVVA was (11.34±11.07) cm³, significantly smaller than IGTVCON (P=0.005). There was no significant difference in the centroid positions of IGTVCON, IGTVV, IGTVA and IGTVVA in three directions (P=0.491, 0.360, 0.136). The Dice′s similarity coefficient (DSCVA) was significantly lower than DSCV and DSCA (P=0.004, 0.030). The tumor displacement measured by the four sets of 4DCT images was similar in the LR direction (P=0.470), and also in the AP direction (P=0.108). For the displacement in the SI direction, LVA scanning was smaller than CON (P=0.015). The radiation doses under four different scanning conditions were (397.0±140.3) mGy·cm,(175.0±61.8) mGy·cm,(264.8±95.3) mGy·cm and (116.8±41.2) mGy·cm, respectively (P<0.001). Conclusions LV or LA scanning exert no significant effect on the volume, centroid position of IGTV and the tumor displacement in 4DCT simulation for SPTs. The radiation dose that patients receive under LV and LV scanning is lower than that of CON. Consequently, LV or LA scanning is feasible in 4DCT simulation and target delineation for SPTs.

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	Shang Dongping
	Luan Lijuan
	Wang Lizhen
	Sun Qingning
	Yu Jinming
	Yin Yong

Key words： Low dose Tomography, X-ray computed, four-dimensional Gross tumor volume Lung neoplasm/radiotherapy

Received: 22 January 2021

Corresponding Authors: Yu Jinming, Email:yujinmingprofessor@163.com;Yin Yong, Email:yongyinsd@163.com

Cite this article:

Shang Dongping,Luan Lijuan,Wang Lizhen et al. Application value of low-dose 4DCT scanning in simulation and target delineation for solitary pulmonary tumors[J]. Chinese Journal of Radiation Oncology, 2022, 31(2): 165-169.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20210122-00037 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2022/V31/I2/165

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