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Prospective study of apatinib combined with chemoradiotherapy for head and neck squamous cell carcinoma
Li Mengmeng, Li Tingting, Cai Feng, Zhang Yajun, Zhang Xianwen, Liu Jingjing, Zhou Yufu, Sun Qian, Wang Gengming, Chen Rujun, Chen Xin, Zha Genlan, Jiang Hao
Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
AbstractObjective To evaluate the efficacy and safety of apatinib in combination with chemoradiotherapy for head and neck squamous cell carcinoma (HNSCC). Methods 37 patients orally received apatinib at 250mg/d during concurrent chemoradiotherapy until completion of radiotherapy, complete remission assessed by imaging examination, the onset of unacceptable toxicity or death. Baseline characteristics,Objective response rates (ORR) and adverse events were assessed in all enrolled patients with complete baseline and safety data. Progression-free survival (PFS) and overall survival (OS) were calculated by Kaplan-Meier method. Prognostic factors were statistically identified using Cox regression models. Results The ORR was 85%(95%CI:72%-98%). The median PFS was 17.9 months and the 2-year OS rate was 62%(95%CI:48%-80%). Ineffective short-term efficacy (HR=0.035, 995%CI:0.02-0.652, P=0.025) was an independent risk factor for poor OS. In addition, ineffective short-term efficacy (HR=0.104, 95%CI:0.017-0.633, P=0.014) and lymphocytopenia (HR=17.539, 95%CI:2.040-150.779, P=0.009) were independent risk factors for poor PFS. Common adverse events (>60%) included lymphocytopenia (76%),leukopenia (68%) and irradiation-induced mucosal injury (65%). The most common treatment-associated grade 3 adverse event was lymphopenia (49%). Conclusions Apatinib combined with chemoradiotherapy yield significant anti-tumor activity for HNSCC with controllable toxicity. For patients with advanced HNSCC, short-term efficacy and lymphocytopenia may be potential predictors for clinical efficacy of apatinib combined with chemoradiotherapy.
. Prospective study of apatinib combined with chemoradiotherapy for head and neck squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2022, 31(2): 125-130.
. Prospective study of apatinib combined with chemoradiotherapy for head and neck squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2022, 31(2): 125-130.
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