时辰化疗联合放疗局部晚期鼻咽癌疗效<i>Meta分析</i>

doi:10.3760/cma.j.cn113030-20210531-00211

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Abstract Objective To systematically compare the efficacy and safety of chrono-chemotherapy combined with radiotherapy in patients with locally advanced nasopharyngeal carcinoma. Methods Seven databases were searched, including the Cochrane Library (Issue 5, 2021), PubMed, Embase, CBM, CNKI, VIP and Wanfang Database. The method ological quality of the eligible studies was evaluated. The Meta-analysis was performed by the Revman 5.3software. Results Sixteen studies consisting of 1275 patients were finally included. Among them, 642 patients were treated with chrono-chemotherapy combined with radiotherapy and 633 patients received conventional chemotherapy combined with radiotherapy. Results showed that compared with conventional chemotherapy group, the effective rate was significantly elevated (OR=1.66,95%CI:1.17-2.34,P=0.004), the incidence of leucopenia, thrombocytopenia, gastrointestinal reaction, grade 3-4 oral mucosal reaction and grade 3-4 radiothermitis was significantly reduced (all P<0.001), and the quantity of CD3, CD4 and CD4/CD8 was significantly increased in the chrono-chemotherapy group. Conclusion Current evidence shows that compared with conventional chemotherapy, chrono-chemotherapy combined with radiotherapy could improve the effective rate, reduce adverse reactions and mitigate the destruction of immune function simultaneously.

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	Articles by authors
	Yang Jianquan
	Guo Wen
	Lang Jinyi
	Lu Man

Key words： Nasopharyngeal neoplasm/chrono-chemotherapy Nasopharyngeal neoplasm/radiotherapy Meta-analysis

Received: 31 May 2021

Corresponding Authors: Lang Jinyi, Email:langyj60@163.com;Lu Man, Email:graceof@163.com

Cite this article:

Yang Jianquan,Guo Wen,Lang Jinyi et al. Meta-analysis of chrono-chemotherapy combined with radiotherapy for locally advanced nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2022, 31(2): 120-124.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20210531-00211 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2022/V31/I2/120

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