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Effect of Onodera's prognostic nutritional index on the prognosis of esophageal squamous cell carcinoma after intensity-modulated radiotherapy
Yan Ke1, Zhao Hanjun2, Deng Wenzhao1, Wang Xiaobin1, Du Xingyu1, Shen Wenbin1, Zhu Shuchai1
1Department of Radiation Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China; 2Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
AbstractObjective To investigate the relationship between Onodera's prognostic nutritional index (PNI) and prognosis of patients with esophageal squamous cell carcinoma (ESCC) after definitive chemoradiotherapy or radiotherapy, aiming to provide a convenient, effective and accurate predictive indicator for evaluating the long-term survival of patients after treatment. Methods Clinical data of 231 ESCC patients treated with definitive chemoradiotherapy or radiotherapy at the Fourth Hospital of Hebei Medical University from 2013 to 2015 were retrospectively analyzed. The PNI values of each patient at different radiotherapy periods were calculated and the ROC curve was used to determine the optimal cutoff value of PNI before radiotherapy, 231 patients were divided into the better-nourishment group (n=86) and worse-nourishment group (n=145). Kaplan-Meier method was used for survival analysis. Cox proportional hazards model was utilized to analyze the relationship between different nutritional status and prognosis. The short-term clinical efficacy and incidence of acute toxicities were statistically compared between two groups. Results The mean values of PNI before, at week 3, week 6 and 1 month after radiotherapy were48.68±5.08,39.68±4.87,43.74±4.89 and48.31±4.92, respectively. The optimal cutoff value of pretreatment PNI was 49.25, the area under the curve (AUC) was 0.655, the sensitivity and specificity were 68.6% and 60.9%, respectively. The 5-year overall survival (OS) and progression-free survival (PFS) rates in the better-nourishment group (PNI≥49.25) were 36.0% and 31.3%, significantly better than 19.3% and 18.6% in the worse-nourishment group (PNI<49.25)(P=0.001,P=0.039). Multivariate analysis showed PNI before the therapy was an independent prognostic factor for OS (P=0.021). Stratified analysis demonstrated that Stage Ⅰ/Ⅱ and concurrent chemotherapy patients in the better-nourishment group all obtained significantly better OS than their counterparts in the worse-nourishment group (P=0.007,P=0.004). In addition, the Objective response rate in the better-nourishment group was significantly higher than that in the worse-nourishment group (P=0.047), whereas the incidence of ≥3 grade radiation esophagitis was lower than that in the worse-nourishment group (P=0.060). Conclusions Pretreatment PNI is a convenient and reliable indicator for predicting the long-term survival of ESCC patients after definitive chemoradiotherapy or radiotherapy. Patients with higher PNI have relatively better prognosis and radiotherapy tolerance, especially in those with early stage or concurrent chemotherapy.
Yan Ke,Zhao Hanjun,Deng Wenzhao et al. Effect of Onodera's prognostic nutritional index on the prognosis of esophageal squamous cell carcinoma after intensity-modulated radiotherapy[J]. Chinese Journal of Radiation Oncology, 2021, 30(11): 1105-1110.
Yan Ke,Zhao Hanjun,Deng Wenzhao et al. Effect of Onodera's prognostic nutritional index on the prognosis of esophageal squamous cell carcinoma after intensity-modulated radiotherapy[J]. Chinese Journal of Radiation Oncology, 2021, 30(11): 1105-1110.
[1] Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6):394-424. DOI:10.3322/caac.21492. [2] Zeng H, Zheng R, Zhang S, et al. Esophageal cancer statistics in China, 2011:estimates based on 177 cancer registries[J]. Thorac Cancer, 2016, 7(2):232–237. DOI:10.1111/1759-7714.12322. [3] Chun SG, Skinner HD, Minsky BD. Radiation therapy for locally advanced esophageal cancer[J]. Surg Oncol Clin N Am, 2017, 26(2):257-276. DOI:10.1016/j.soc.2016.10.006. [4] Bozzetti F, Mariani L, Lo Vullo S, et al. The nutritional risk in oncology:a study of 1453 cancer outpatients[J]. Support Care Cancer, 2012, 20(8):1919-1928. DOI:10.1007/s00520-012-1387-x. [5] 魏学燕,韩光,吴媛,等. 局部晚期鼻咽癌患者营养状况及其与预后相关性分析[J]. 中国肿瘤临床,2020,47(6):282-288. DOI:10.3969/j.issn.1000-8179.2020.06.271. Wei XY, Han G, Wu Y, et al. Nutritional status and its relation ship with prognosis in patients with locally advanced nasopharyngeal carcinoma[J]. Chin J Clin Oncol, 2020, 47(6):282-288. DOI:10.3969/j.issn.1000-8179.2020.06.271. [6] Liu X, Qiu H, Kong P, et al. Gastric cancer, nutritional status, and outcome[J]. Oncol Targets Ther, 2017, 10:2107-2114. DOI:10.2147/OTT. S132432. [7] Sun P, Zhang F, Chen C, et al. Comparison of the prognostic values of various nutritional parameters in patients with esophageal squamous cell carcinoma from Southern China[J]. J Thorac Dis, 2013, 5(4):484-491. DOI:10.3978/j.issn.2072-1439.2013.08.38. [8] Onodera T, Goseki N, Kosaki G. Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients[J]. Nihon Geka Gakkai Zasshi, 1984, 85(9):1001-1005. [9] Wang D, Hu X, Xiao L, et al. Prognostic nutritional index and systemic immune-inflammation index predict the prognosis of patients with HCC[J]. J Gastrointest Surg, 2021, 25(2):421-427. DOI:10.1007/s11605-019-04492-7. [10] Yang Y, Gao P, Chen X, et al. Prognostic significance of preoperative prognostic nutritional index in colorectal cancer:results from a retrospective cohort study and a meta analysis[J]. Oncotarget, 2016, 7(36):58543-58552. DOI:10.18632/oncotarget.10148. [11] Park S, Ahn HJ, Yang M, et al. The prognostic nutritional index and postoperative complications after curative lung cancer resection:A retrospective cohort study[J]. J Thorac Cardiovasc Surg, 2020, 160(1):276-285. DOI:10.1016/j.jtcvs.2019.10.105. [12] Dai Y, Fu X, Li T, et al. Long-term impact of prognostic nutritional index in cervical esophageal squamous cell carcinoma patients undergoing definitive radiotherapy[J]. Ann Transl Med, 2019, 7(8):175. DOI:10.21037/atm.2019.03.60. [13] Laviano A, Di Lazzaro L, Koverech A. Nutrition support and clinical outcome in advanced cancer patients[J]. Proc Nutr Soc, 2018, 77(4):388-393. DOI:10.1017/S0029665118000459. [14] Kim S, McClave SA, Martindale RG, et al. Hypoalbuminemia and clinical outcomes:what is the mechanism behind the relationship?[J]. Am Surg, 2017, 83(11):1220-1227. DOI:10.1177/000313481708301123. [15] Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation[J]. Nature, 2008, 454(7203):436-444. DOI:10.1038/nature07205. [16] Inada M, Nishimura Y, Ishikawa K, et al. Comparing the7th and8th editions of the American Joint Committee on Cancer/Union for international cancer control TNM staging system for esophageal squamous cell carcinoma treated by definitive radiotherapy[J]. Esophagus, 2019, 16(4):371-376. DOI:10.1007/s10388-019-00675-y. [17] Yao B, Tan B, Wang C, et al. Comparison of definitive chemoradiotherapy in locally advanced esophageal squamous cell carcinoma[J]. Ann Surg Oncol, 2016, 23(7):2367-2372. DOI:10.1245/s10434-016-5154-y. [18] 吴婧文,于学娟,杨秋安. 小野寺预后营养指数与食管鳞癌同步放化疗不良反应的相关性研究[J]. 中国癌症杂志,2020,30(7):525-530. DOI:10.19401/j.cnki.1007-3639.2020.07.007. Wu JW, Yu XJ, Yang QA. Association between Onodera's prognostic nutrition index and adverse effects of concurrent chemoradiotherapy for esophageal squamous cell carcinoma[J]. Chin Oncol, 2020, 30(7):525-530. DOI:10.19401/j.cnki.1007-3639.2020.07.007. [19] 杨圣思,程玉峰. 小野寺指数在老年食管癌放射治疗中的临床应用[J]. 山东大学学报(医学版),2015, 53(6):54-57,62. DOI:10.6040/j.issn.1671-7554.0.2014.718. Yang SS, Cheng YF. Application of Onodera prognostic nutrition index in elderly patients with esophageal carcinoma treated with radiotherapy[J]. J Shandong Univ (Health Sci), 2015, 53(6):54-57,62. DOI:10.6040/j.issn.1671-7554.0.2014.718.