[an error occurred while processing this directive] | [an error occurred while processing this directive]
Research progress on tumor hyperthermia
Zhao Yanyan, Xu Yasi, Wu Qiong, Ma Shenglin, Zhang Shirong
Department of Translation Medicine Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People′s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
Abstract In recent years, increasing evidence has shown that hyperthermia is safe, effective and causes low toxicity. Hyperthermia can exert synergistic effect with other treatments, such as radiotherapy and chemotherapy. It has become an important adjuvant anti-tumor treatment secondary to surgery, chemotherapy, radiotherapy and biological treatment. Hyperthermia can improve the efficacy of radiotherapy and chemotherapy by directly inhibiting tumor cells and heat-induced radiosensitizing effect. Hence, hyperthermia is gradually applied in the multimodality treatment of tumors. In this article, we intend to review the research progress on the application of tumor hyperthermia in conventional radiotherapy, chemotherapy, immunotherapy and new biomaterials.
Fund:Hangzhou Science and Technology Development Program (20180533B41);Zhejiang Medical and Health Technology Project (2018KY580);Hangzhou Science and Technology Development Major Project (20180417A01)
[1] Cihoric N, Tsikkinis A, van Rhoon G, et al. Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry[J]. Int J Hyperthermia, 2015, 31(6):609-614. DOI:10.3109/02656736.2015.1040471. [2] 马胜林,张珊文,肖绍文. 中国肿瘤热疗临床应用指南(2017. V 1.1)[J]. 中华放射肿瘤学杂志,2017, 26(4):369-375. Ma SL, Zhang SW, Xiao SW. Chinese clinical application guidelines for tumor thermotherapy (2017. V 1.1)[J]. Chin J Radiat Oncol, 2017, 26(4):369-375. [3] 中国临床肿瘤学会肿瘤热疗专家委员会,中日医学科技交流协会热疗专家委员会,中华医学会放疗分会热疗学组. 肿瘤热疗中国专家共识[J]. 实用肿瘤杂志,2020, 35(1):1-10. DOI:10.13267/j.cnki.syzlzz.2020.01.001. Expert Committee on Tumor Thermotherapy of the Chinese Society of Clinical Oncology, Expert Committee on Thermotherapy of the China-Japan Medical Science and Technology Exchange Association, Thermotherapy Group of the Radiotherapy Branch of the Chinese Medical Association. Chinese expert consensus on tumor thermotherapy[J]. J Pract Oncol, 2020, 35(1):1-10. DOI:10.13267/j.cnki.syzlzz.2020.01.001. [4] Ju H, Mao L, Zhang L, et al. Ultrasound hyperthermia enhances chemo-sensitivity in oral squamous cell carcinoma by TRIF-mediated pathway[J]. J Oral Pathol Med, 2018, 47(10):964-971. DOI:10.1111/jop.12774. [5] Mu C, Wu X, Zhou X, et al. Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple-negative breast cancer[J]. Clin Cancer Res, 2018, 24(19):4900-4912. DOI:10.1158/1078-0432. CCR-17-3872. [6] van Driel WJ, Koole SN, Sikorska K, et al. Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer[J]. N Engl J Med, 2018, 378(3):230-240. DOI:10.1056/NEJMoa1708618. [7] Ji ZH, Peng KW, Yu Y, et al. Current status and future prospects of clinical trials on CRS+ HIPEC for gastric cancer peritoneal metastases[J]. Int J Hyperthermia, 2017, 33(5):562-570. DOI:10.1080/02656736.2017.1283065. [8] Lowenfeld L, Datta J, Lewis RS Jr, et al. Multimodality treatment of T4 gastric cancer in the united states:utilization trends and impact on survival[J]. Ann Surg Oncol, 2015, 22 suppl 3:S863-872. DOI:10.1245/s10434-015-4677-y. [9] Wang QW, Zhang XT, Lu M, et al. Impact of duration of adjuvant chemotherapy in radically resected patients with T4bN1-3M0/TxN3bM0 gastric cancer[J]. World J Gastrointest Oncol, 2018, 10(1):31-39. DOI:10.4251/wjgo.v10.i1.31. [10] Wu Z, Ma S, Jing S, et al. Effect of hyperthermic intraperitoneal perfusion chemotherapy in combination with intravenous chemotherapy as postoperative adjuvant therapy for advanced gastric cancer[J]. Hepatogastroenterology, 2014, 61(132):972-977. [11] Zhu L, Xu Y, Shan Y, et al. Intraperitoneal perfusion chemotherapy and whole abdominal hyperthermia using external radiofrequency following radical D2 resection for treatment of advanced gastric cancer[J]. Int J Hyperthermia, 2019, 36(1):403-407. DOI:10.1080/02656736.2019.1579372. [12] Issels RD, Lindner LH, Verweij J, et al. Effect of neoadjuvant chemotherapy plus regional hyperthermia on long-term outcomes among patients with localized high-risk soft tissue sarcoma:the EORTC 62961-ESHO 95 randomized clinical trial[J]. JAMA Oncol, 2018, 4(4):483-492. DOI:10.1001/jamaoncol.2017.4996. [13] Fang H, Zhang Y, Wu Z, et al. Regional hyperthermia combined with chemotherapy in advanced gastric cancer[J]. Open Med (Wars), 2019, 14:85-90. DOI:10.1515/med-2019-0012. [14] Dikomey E, Franzke J. Effect of heat on induction and repair of DNA strand breaks in X-irradiated CHO cells[J]. Int J Radiat Biol, 1992, 61(2):221-233. DOI:10.1080/09553009214550851. [15] van der Zee J, Gonzalez Gonzalez D, van Rhoon GC, et al. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours:a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group[J]. Lancet, 2000, 355(9210):1119-1125. DOI:10.1016/s0140-6736(00)02059-6. [16] Jones EL, Oleson JR, Prosnitz LR, et al. Randomized trial of hyperthermia and radiation for superficial tumors[J]. J Clin Oncol, 2005, 23(13):3079-3085. DOI:10.1200/JCO.2005.05.520. [17] Kok HP, Van Dijk I, Crama KF, et al. Reirradiation plus hyperthermia for recurrent pediatric sarcoma;a simulation study to investigate feasibility[J]. Int J Oncol, 2019, 54(1):209-218. DOI:10.3892/ijo.2018.4622. [18] Dharmaiah S, Zeng J, Rao VS, et al. Clinical and dosimetric evaluation of recurrent breast cancer patients treated with hyperthermia and radiation[J]. Int J Hyperthermia, 2019, 36(1):986-992. DOI:10.1080/02656736.2019.1660810. [19] Chi MS, Yang KL, Chang YC, et al. Comparing the effectiveness of combined external beam radiation and hyperthermia versus external beam radiation alone in treating patients with painful bony metastases:a phase 3 prospective, randomized, controlled trial[J]. Int J Radiat Oncol Biol Phys, 2018, 100(1):78-87. DOI:10.1016/j.ijrobp.2017.09.030. [20] Merten R, Ott O, Haderlein M, et al. Long-term experience of chemoradiotherapy combined with deep regional hyperthermia for organ preservation in high-risk bladder cancer (Ta, Tis, T1, T2)[J]. Oncologist, 2019, 24(12):e1341-e1350. DOI:10.1634/theoncologist.2018-0280. [21] Cheng Y, Weng S, Yu L, et al. The Role of Hyperthermia in the multidisciplinary treatment of malignant tumors[J]. Integr Cancer Ther, 2019, 18:1534735419876345. DOI:10.1177/15347354 19876345. [22] Lin C, Zhang Y, Zhang K, et al. Fever Promotes T lymphocyte trafficking via a thermal sensory pathway involving heat shock protein 90 and α4 integrins[J]. Immunity, 2019, 50(1):137-151 e6. DOI:10.1016/j.immuni.2018.11.013. [23] Toraya-Brown S, Fiering S. Local tumour hyperthermia as immunotherapy for metastatic cancer[J]. Int J Hyperthermia, 2014, 30(8):531-539. DOI:10.3109/02656736.2014.968640. [24] Mahmood J, Shukla HD, Soman S, et al. Immunotherapy, radiotherapy, and hyperthermia:a combined therapeutic approach in pancreatic cancer treatment[J]. Cancers (Basel), 2018, 10(12):469. DOI:10.3390/cancers10120469. [25] Ando K, Suzuki Y, Kaminuma T, et al. Tumor-specific CD8-positive T cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia[J]. Int J Hyperthermia, 2018, 35(1):226-231. DOI:10.1080/02656736.2018.1492027. [26] Bull JMC. A review of immune therapy in cancer and a question:can thermal therapy increase tumor response?[J]. Int J Hyperthermia, 2018, 34(6):840-852. DOI:10.1080/02656736. 2017. 13879 38. [27] Kleef R, Moss R, Szasz AM, et al. Complete clinical remission of stage IV triple-negative breast cancer lung metastasis administering low-dose immune checkpoint blockade in combination with hyperthermia and interleukin-2[J]. Integr Cancer Ther, 2018, 17(4):1297-1303. DOI:10.1177/1534735418794867. [28] Huang L, Li Y, Du Y, et al. Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy[J]. Nat Commun, 2019, 10(1):4871. DOI:10.1038/s41467-019-12771-9. [29] van der Horst A, Versteijne E, Besselink MGH, et al. The clinical benefit of hyperthermia in pancreatic cancer:a systematic review[J]. Int J Hyperthermia, 2018, 34(7):969-979. DOI:10.1080/02656736.2017.1401126. [30] Bai Z, Shi Y, Wang J, et al. Intratumoral radiofrequency hyperthermia-enhanced direct chemotherapy of pancreatic cancer[J]. Oncotarget, 2017, 8(2):3591-3599. DOI:10.18632/oncotarget.12295. [31] Wang R, He Z, Cai P, et al. Surface-Functionalized Modified Copper Sulfide Nanoparticles Enhance Checkpoint Blockade Tumor Immunotherapy by Photothermal Therapy and Antigen Capturing[J]. ACS Appl Mater Interfaces, 2019, 11(15):13964-13972. DOI:10.1021/acsami.9b01107. [32] Azad A, Yin Lim S, D′Costa Z, et al. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy[J]. EMBO Mol Med, 2017, 9(2):167-180. DOI:10.15252/emmm.201606674. [33] Feng J, Sheng H, Zhu C, et al. Effect of adjuvant magnetic fields in radiotherapy on non-small-cell lung cancer cells in vitro[J]. Biomed Res Int, 2013, 2013:657259. DOI:10.1155/2013/657259. [34] Hu R, Ma S, Li H, et al. Effect of magnetic fluid hyperthermia on lung cancer nodules in a murine model[J]. Oncol Lett, 2011, 2(6):1161-1164. DOI:10.3892/ol.2011.379. [35] Ren X, Zheng R, Fang X, et al. Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy[J]. Biomaterials, 2016, 92:13-24. DOI:10.1016/j.biomaterials.2016.03.026. [36] Hu Y, Mignani S, Majoral JP, et al. Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy[J]. Chem Soc Rev, 2018, 47(5):1874-1900. DOI:10.1039/c7cs00657h. [37] Atkinson RL, Zhang M, Diagaradjane P, et al. Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy[J]. Sci Transl Med, 2010, 2(55):55ra79. DOI:10.1126/scitranslmed.3001447. [38] Cheng X, Yong Y, Dai Y, et al. Enhanced radiotherapy using bismuth sulfide nanoagents combined with photo-thermal treatment[J]. Theranostics, 2017, 7(17):4087-4098. DOI:10.7150/thno.20548. [39] Chen Q, Hu Q, Dukhovlinova E, et al. Photothermal therapy promotes tumor infiltration and antitumor activity of CAR T Cells[J]. Adv Mater, 2019, 31(23):e1900192. DOI:10.1002/adma.201900192.
2021, Vol. 30 
