Abstract Primary tracheal adenoid cystic carcinoma (TACC) is exceedingly rare. Surgical resection is the main treatment for TACC. Whether the operation is radical or not is a key prognostic factor. Postoperative radiotherapy may be suitable to improve the local control rate and long-term survival for patients with positive surgical margin. For unresectable, recurrent and metastatic TACC patients, definitive radiotherapy, chemotherapy and molecular targeted therapies have yielded certain clinical efficacy. The aim of this review is to summarize the research progress on multimodality treatment for TACC.
Fund:2019 Gansu Province Health Industry Scientific Research Management Project (GSWSKY-2019-79);First Hospital of Lanzhou Hospital Funding Support Project (ldyyyn2018-21)
Cite this article:
Qu Guofeng,Ran Juntao. Research progress on multimodality treatment for primary tracheal adenoid cystic carcinoma[J]. Chinese Journal of Radiation Oncology, 2021, 30(8): 858-861.
Qu Guofeng,Ran Juntao. Research progress on multimodality treatment for primary tracheal adenoid cystic carcinoma[J]. Chinese Journal of Radiation Oncology, 2021, 30(8): 858-861.
[1] Alongi F, Di Muzio N, Motta M, et al. Adenoid cystic carcinoma of trachea treated with adjuvant hypofractionated tomotherapy. Case report and literature review[J]. Tumori, 2008, 94(1):121-125. [2] Charlton P, Pitkin L. Airway compromise due to adenoid cystic carcinoma obstructing the distal trachea:a review of current management and clinical trials[J]. BMJ Case Rep, 2015, 14(1):1-3. DOI:10.1136/bcr-2014-204063. [3] Honings J, Gaissert HA, Weinberg AC, et al. Prognostic value of pathologic characteristics and resection margins in tracheal adenoid cystic carcinoma[J]. Eur J Cardiothorac Surg, 2010, 37(6):1438-1444. DOI:10.1016/j.ejcts.2010.01.005. [4] Levy A, Omeiri A, Fadel E, et al. Radiotherapy for tracheal-bronchial cystic adenoid carcinomas[J]. Clin Oncol (R Coll Radiol), 2018, 30(1):39-46. DOI:10.1016/j.clon.2017.10.012. [5] Yang H, Yao F, Tantai J, et al. Resected tracheal adenoid cystic carcinoma:improvements in outcome at a single institution[J]. Ann Thorac Surg, 2016, 101(1):294-300. DOI:10.1016/j.athoracsur.2015.06.073. [6] 梁军,王绿化. 气管腺样囊性癌诊治研究[J]. 实用肿瘤杂志,2009, 24(2):206-208. DOI:10.13267/j.cnki.syzlzz.2009.02.031. Liang J, Wang LH. Study on the diagnosis and treatment of tracheal adenoid cystic carcinoma[J]. J Pract Oncol, 2009, 24(2):206-208. DOI:10.13267/j.cnki.syzlzz. 2009.02.031. [7] Clough A, Clarke P. Adenoid cystic carcinoma of the trachea:a long-term problem[J]. AN Z J Surg, 2006, 76(8):751-753. DOI:10.1111/j.1445-2197.2006.03848.x. [8] Bhattacharyya N. Contemporary staging and prognosis for primary tracheal malignancies:a population-based analysis[J]. Otolaryngol Head Neck Surg, 2004, 131(5):639-642. DOI:10.1016/j.otohns.2004.05.018. [9] Macchiarini P. Primary tracheal tumours[J]. Lancet Oncol, 2006, 7(1):83-91. DOI:10.1016/S1470-2045(05)70541-6. [10] Sayar A, Metin M, Solak O, et al. A new surgical technique for adenoid cystic carcinoma involvingtracheal carina[J]. Asian Cardiovasc Thorac Ann, 2005, 13(3):280-282. DOI:10.1177/021849230501300320. [11] Suzuki T. What is the best management strategy for adenoid cystic carcinoma of the trachea?[J]. Ann Thorac Cardiovasc Surg, 2011, 17(6):535-538. DOI:10.5761/atcs.ed.11.01823. [12] Maziak DE. Biology of Adenoid cystic carcinoma of the tracheobronchial tree and principles of management[J]. Thorac Surg Clin, 2018, 28(2):145-148. DOI:10.1016/j.thorsurg.2018.01.002. [13] 梁军,王文卿,陈东福, 等.74例原发性气管腺样囊性癌的临床分析[J]. 实用肿瘤杂志,2009, 24(4):381-384. DOI:10.13267/j.cnki.syzlzz.2009.04.017. Liang J, Wang WQ, Chen DF, e al. Clinical analysis of 74 cases of primary tracheal adenoid cystic carcinoma[J]. J Pract Oncol, 2009, 24(4):381-384. DOI:10.13267/j.cnki.syzlzz.2009.04.017. [14] Wo Y, Li S, Wang Y, et al. Predictors of nodal metastasis and prognostic significance of lymph node ratio and total lymph node count in tracheobronchial adenoid cystic carcinoma[J]. Cancer Manag Res, 2018, 10:5919-5925. DOI:10.2147/CMAR. S182069. [15] Högerle BA, Lasitschka F, Muley T, et al. Primary adenoid cystic carcinoma of the trachea:clinical outcome of 38 patients after interdisciplinary treatment in a single institution[J]. Radiat Oncol, 2019, 14(1):117. DOI:10.1186/s13014-019-1323-z. [16] Zhao Y, Zhao H, Fan L, et al. Adenoid cystic carcinoma in the bronchus behaves more aggressively than its tracheal counterpart[J]. Ann Thorac Surg, 2013, 96(6):1998-2004. DOI:10.1016/j.athoracsur.2013.08.009. [17] Gaissert HA, Grillo HC, Shadmehr MB, et al. Long-term survival after resection of primary adenoid cystic and squamous cell carcinoma of the trachea and carina[J]. Ann Thorac Surg, 2004, 78(6):1889-1897. DOI:10.1016/j.athoracsur.2004.05.064. [18] 王永岗,张汝刚,张宏图等. 气管、支气管囊性腺癌[J]. 中华胸心血管外科杂志,2000, 16(6):357-358. Wang YG, Zhang RG, Zhang HT, et al. Bronchial and bronchial cystic adenocarcinoma[J]. Chin J Chest Cardiovas Surg, 2000, 16(6):357-358 [19] Je HU, Song SY, Kim DK, et al. A 10-year clinical outcome of radiotherapy as an adjuvant or definitive treatment for primary tracheal adenoid cystic carcinoma[J]. Radiat Oncol, 2017, 12(1):196. DOI:10.1186/s13014-017-0933-6. [20] Hu MM, Hu Y, He JB, et al. Primary adenoid cystic carcinoma of the lung:Clinicopathological featuress,treatment and results[J]. Oncol Lett, 2015, 9(3):1475-1481. DOI:10.3892/ol.2015.2859. [21] Calzada AP, Miller M, Lai CK, et al. Adenoid cystic carcinoma of the airway:a 30-year review at one institution[J]. Am J Otolaryngol, 2012, 33(2):226-231. DOI:10.1016/j.amjoto.2011.07.003. [22] Chen F, Huang M, Xu Y, et al. Primary tracheal adenoid cystic carcinoma:adjuvant treatment outcome[J]. Int J Clin Oncol, 2015, 20(4):686-692. DOI:10.1007/s10147-014-0771-6. [23] Yang CJ, Shah SA, Ramakrishnan D. Impact of positive margins and radiation after tracheal adenoid cystic carcinoma resection on survival[J]. Ann Thorac Surg, 2019, 109(4):1026-1032. DOI:org/10.1016/j.athoracsur.2019.08.094 [24] Yusuf M, Gaskins J, Trawick E, et al. Effects of adjuvant radiation therapy on survival for patients with resected primary tracheal carcinoma:an analysis of the National Cancer Database[J]. Jpn J Clin Oncol, 2019, 49(7):628-638. DOI:10.1093/jjco/hyz047. [25] Agrawal S, Jackson C, Celie KB, et al. Survival trends in patients with tracheal carcinoma from 1973 to 2011[J]. Am J Otolaryngol, 2017, 38(6):673-677. DOI:10.1016/j.amjoto.2017.08.005. [26] Allen A, Rabin MS, Reilly JJ, et al. Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation[J]. J Clin Oncol, 2007, 25(34):5521-5523. DOI:10.1200/JCO.2007.13.7273. [27] Varghese A, Suneha S, Watkinson JC. Adenoid Cystic Carcinoma of Trachea[J]. Indian J Surg, 2017, 79(1):67-69. DOI:10.1007/s12262-016-1457-2. [28] Haddad RI, Posner MR, Busse PM, et al. Chemoradiotherapy for adenoid cystic carcinoma:preliminary results of an organ sparing approach[J]. Am J Clin Oncol, 2006, 29(2):153-157. DOI:10.1097/01.coc.0000203756.36866.17. [29] Licht PB, FrⅡs S, Pettersson G. Tracheal cancer in Denmark:a nationwide study[J]. Eur J Cardiothorac Surg, 2001, 19(3):339-345. DOI:10.1016/s1010-7940(01)00597-8. [30] Bittner N, Koh WJ, Laramore GE, et al. Treatment of locally advanced adenoid cystic carcinoma of the trachea with neutron radiotherapy[J]. Int J Radiat Oncol Biol Phys, 2008, 72(2):410-414. DOI:10.1016/j.ijrobp.2008.01.016. [31] Bonner Millar LP, Stripp D, Cooper JD, et al. Definitive radiotherapy for unresected adenoid cystic carcinoma of the trachea[J]. Chest, 2012, 141(5):1323-1326. DOI:10.1378/chest.11-0925. [32] Müller A, Stockamp B, Schnabel T. Successful primary radiation therapy of adenoid cystic carcinoma of the lung[J]. Oncology, 2000, 58(1):15-17. DOI:10.1159/000012073. [33] Laurie SA, Ho AL, Fury MG, et al. Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands:a systematic review[J]. Lancet Oncol, 2011, 12(8):815-824. DOI:10.1016/S1470-2045(10)70245-X. [34] Ning Y, He WX, Bian DL, et al. Tracheo-bronchial adenoid cystic carcinoma:a retrospective study[J]. Asia Pac J Clin Oncol, 2019, 15(4):244-249. DOI:10.1111/ajco.13162. [35] Hotte SJ, Winquist EW, Lamont E, et al. Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit:A princess margaret hospital phase Ⅱ consortium study[J]. J Clin Oncol, 2005, 23(3):585-590. DOI:10.1200/JCO.2005.06.125.
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