AbstractObjective To evaluate the radiosensitivity enhancement effect of FePd@CNTs nanocomposites on human breast cancer MCF-7 cells. Methods FePd@CNTs nanocomposites were synthesized by chemical reduction method. Transmission electron microscope and energy dispersive spectrometer were utilized to characterize the surface morphology and chemical composition of FePd@CNTs nanocomposites. The compatibility of FePd@CNTs nanocomposites with human normal breast epithelial MCF-10A cells was determined by CCK-8 assay. The radiosensitivity enhancement effect of FePd@CNTs nanocomposites on MCF-7 cells was assessed by CCK-8 assay, flow cytometry and clony formation assay. Results FePd nanospheres were successfully modified on the surface of CNTs by chemical reduction method. FePd@CNTs nanocomposites showed a low toxicity to MCF-10A cells (IC50=738.3μg/m), and effectively enhanced the effect of X-ray radiation on MCF-7 cells (sensibilization ratio=1.22). Conclusion FePd@CNTs nanocomposites exhibit a promising potential for treating breast cancer and enhancing radiosensitivity effect.
Fund:Elekta-Wuhan University Medical Physics Teaching and Research Fund (250000200)
Corresponding Authors:
Quan Hong, Email:csp6606@sina.com
Cite this article:
Kong Xiangyue,Lyu Meng,Peng Xiaoqing et al. Radiosensitivity enhancement effect of FePd@CNTs nanocomposites on MCF-7 cells[J]. Chinese Journal of Radiation Oncology, 2021, 30(8): 841-845.
Kong Xiangyue,Lyu Meng,Peng Xiaoqing et al. Radiosensitivity enhancement effect of FePd@CNTs nanocomposites on MCF-7 cells[J]. Chinese Journal of Radiation Oncology, 2021, 30(8): 841-845.
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