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Research progress on hippocampal-avoidance whole brain radiotherapy
Chen Mengyuan, Chen Yuanyuan, Chen Ming, Du Xianghui
Institute of Cancer and Basic Medicine and Chinese Academy of Sciences, Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310000, China
Abstract With the advancement of imaging diagnosis and the development of modern radiotherapy, the survival of cancer patients has been prolonged and the incidence rate of brain metastases (BM) has been significantly increased. The quality of life of patients and potential radiotherapy-induced neurocognitive impairment have gradually captivated widespread attention. Whole brain radiotherapy (WBRT) is one of the common local therapies for BM patients. However,the application of WBRT is controversial because it may lead to neurocognitive impairment. The incidence of metastatic tumors in hippocampus and radiation-induced neurocognitive impairment can accelerate the implementation of hippocampal-avoidance WBRT (HA-WBRT). In this article, the feasibility of HA-WBRT was discussed and research progress in recent years was reviewed.
Fund:National Natural Science Foundation of China (81402540, 81672972);National Health and Family Planning Commission Scientific Research Fund-Zhejiang Province Medical and Health Major Science and Technology Program Provincial Joint Construction Plan Project (WKJ-ZJ-1701)
Corresponding Authors:
Du Xianghui, Email:duxh@zjcc.org.cn;Chen Ming, Email:chenming@zjcc.org.cn
Cite this article:
Chen Mengyuan,Chen Yuanyuan,Chen Ming et al. Research progress on hippocampal-avoidance whole brain radiotherapy[J]. Chinese Journal of Radiation Oncology, 2021, 30(7): 735-738.
Chen Mengyuan,Chen Yuanyuan,Chen Ming et al. Research progress on hippocampal-avoidance whole brain radiotherapy[J]. Chinese Journal of Radiation Oncology, 2021, 30(7): 735-738.
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