放射性肺损伤与铁死亡相关性研究进展

doi:10.3760/cma.j.cn113030-20200506-00231

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Abstract Radiation-induced lung injury (RILI) is a common complication after radiotherapy for lung cancer and alternative thoracic malignant tumors, while ferroptosis is a regulated cell death triggered by iron-dependent membrane lipid peroxidation. In this article, the relationship between RILI and ferroptosis was investigated from oxidative damage induced by reactive oxygen species, antioxidant network and iron homeostasis regulated by nuclear factor erythroid 2-related factor 2(Nrf2) as well as transforming growth factor involved in the inflammatory response, aiming to mitigate or inhibit the occurrence of RILI through regulating ferroptosis, thereby improving clinical prognosis of patients undergoing radiotherapy.

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	Articles by authors
	Zheng Yuming
	Jiang Mawei
	Zheng Leizhen
	Zhu Meiling

Key words： Radiation-induced lung injury Ferroptosis Progression

Received: 06 May 2020

Fund:Young Scientists Fund of National Natural Science Foundation of China (81602666);Shanghai Pujiang Talent Program (2019PJD034)

Corresponding Authors: Zheng Leizhen, Email:zhengleizhen@xinhuamed.com.cn;Zhu Meiling, Email:zhumeiling@xinhuamed.com.cn

Cite this article:

Zheng Yuming,Jiang Mawei,Zheng Leizhen et al. Research progress on the association between radiation-induced lung injury and ferroptosis[J]. Chinese Journal of Radiation Oncology, 2021, 30(5): 527-530.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20200506-00231 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I5/527

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