术后放疗在Ⅲ(pN2)期EGFR基因野生型肺腺癌辅助化疗患者中价值

doi:10.3760/cma.j.cn113030-20210130-00052

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Abstract Objective To evaluate the value and identify the prognosic factors of postoperative radiotherapy (PORT) in completely resected stage Ⅲ(pN2) lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) wild-type who received adjuvant chemotherapy. Methods Clinical data of 172 patients with stage Ⅲ(pN2) EGFR wild-type lung adenocarcinoma who underwent radical resection and adjuvant chemotherapy from 2009 to 2016 were retrospectively analyzed. All patients received platinum-based adjuvant chemotherapy combining two drugs for>4 cycles, and divided into the PORT group and the non-PORT group. The survival rate was calculated by Kaplan-Meier method and log-rank test, and multivariate prognostic analysis was performed by Cox’s regression model. Results Among 172 patients, the median overall survival (OS), 3-year and 5-year OS rates were 40 months, 55.9% and 28.3%, respectively. The median disease-free survival (DFS), 3-year and 5-year DFS rates were 17 months, 24.5% and 13.0%, respectively. DFS was significantly improved in the PORT group (29 months vs. 13 months, P=0.001), whereas OS did not significantly differ between two groups (51 months vs. 38 months,P=0.151). In subgroup analysis,DFS of patients with multistation N2 or the number of N2 metastases of≥3 or skip N2 in the PORT group was significantly longer (P<0.05), whereas PORT exerted no significant effect on OS (P>0.05). Conclusions For patients with completely resected stage Ⅲ(N2) EGFR wild-type lung adenocarcinoma receiving adjuvant chemotherapy, PORT might increase DFS and have a trend toward longer OS. However, these findings remain to be validated by large sample size investigations.

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	Articles by authors
	He Chunyu
	Ma Cong
	Chen Huijing
	Nie Xin
	Li Peng
	Wu Xiaoyuan
	Zhang Chengjuan
	Wang Zongfei
	Liu Baoxing
	Liu Ru
	Ge Hong

Key words： Lung neoplasm/adenocarcinoma Stage Ⅲ(N2) Epidermal growth factor receptor wild-type Postoperative radiotherapy Prognosis

Received: 30 January 2021

Fund:Project of Tackling Key Problems in Technology of Henan Province (202102310114)

Corresponding Authors: Liu Ru, Email:13938508576@163.com

Cite this article:

He Chunyu,Ma Cong,Chen Huijing et al. Efficacy of postoperative radiotherapy and prognosis in patients with completely resected stage Ⅲ(pN2) lung adenocarcinoma with EGFR wild-type receiving adjuvant chemotherapy[J]. Chinese Journal of Radiation Oncology, 2021, 30(5): 451-456.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20210130-00052 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I5/451

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