局部晚期不可手术食管癌同步放化疗联合尼妥珠单抗的初步临床分析

doi:10.3760/cma.j.cn113030-20210127-00046

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Abstract Objective The standard treatment for inoperable locally advanced esophageal cancer is concurrent chemoradiotherapy, but the survival was not satisfied. Nituzumab is a humanized IgG monoclonal antibody against EGFR. The purpose of this study is to investigate the toxicity and efficacy of concurrent chemoradiotherapy combined with nituzumab for locally advanced esophageal cancer. Methods We retrospectively reviewed the clinical data of locally advanced esophageal cancer who were treated with concurrent chemoradiotherapy combined with nituzumab in Peking University Cancer Hospital from June 2015 to June 2020. Kaplan-Meier method was used for analysis. Results Thirty Patients were enrolled this study.After a median follow-up of 22.5 months, The objective response rate was 93%. The 1-year, 2-year, 3-year overall survival rates were 83%, 57% and 41%,with the progression-free survival rates 75%, 47% and 32%, with the local-recurrence free survival rates 83%, 53% and 37%, with the metastasis-free survival rates 75%, 51% and 36%, respectively.The incidence of grade≥3 hematological toxicity was 32%. There were 16% patients experiencing grade≥3 esophagitis. Conclusion The preliminary result of concurrent chemoradiotherapy combined with nituzumab is effective and safe for patients with locally advanced esophageal cancer.

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	Articles by authors
	Zeng Cheng
	Yang Dan
	Du Rongxu
	Jiang Leilei
	Dong Xin
	Li Dongming
	Yu Rong
	Yu Huiming
	Shi Anhui

Key words： Esophageal neoplasms/concurrent chemoradiotherapy Esophageal neoplasms/target therapy Treatment outcome

Received: 27 January 2021

Fund:Beijing Municipal Health Commission (BHTPP202026)

Corresponding Authors: Shi Anhui, Email:anhuidoctor@163.com

Cite this article:

Zeng Cheng,Yang Dan,Du Rongxu et al. Preliminary clinical analysis of concurrent chemoradiotherapy combined with nituzumab for inoperable locally advanced esophageal cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(4): 353-356.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20210127-00046 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I4/353

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