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Research progress on the mechanism of radiation-induced lung injury
Ying Hangjie, Chen Yamei, Chen Mengyuan, Fang Min, Chen Ming
Department of Radiation Oncology, Zhejiang Cancer Hospital, Cancer Hospital of University of Chinese Academy of Sciences, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Hangzhou 310022, China
Abstract Radiation-induced lung injury (RILI) is a common complication in thoracic cancer patients through radiotherapy, which can be divided into the early-stage radiation-induced pneumonitis (RP) and late-stage radiation-induced lung fibrosis (RILF). At present, glucocorticoids are mainly adopted in the clinical treatment of RP. However, there has been no effective medical treatment for RILF. RILF patients will eventually die from respiratory failure. The exact mechanism of RILI remains unclear. Current studies have proposed that its possible pathogenesis might consist of genetic heterogeneity, oxidative stress and cell damage. In this review, studies related to the pathogenesis of RILI were summarized.
Fund:National Natural Science Foundation of China (81703018);Natural Science Fund of Zhejiang Province (LQ17H80003);Medical and Healthy Science and Technology Plan Project of Zhejiang Province (2016KYA048)
Ying Hangjie,Chen Yamei,Chen Mengyuan et al. Research progress on the mechanism of radiation-induced lung injury[J]. Chinese Journal of Radiation Oncology, 2021, 30(2): 213-216.
Ying Hangjie,Chen Yamei,Chen Mengyuan et al. Research progress on the mechanism of radiation-induced lung injury[J]. Chinese Journal of Radiation Oncology, 2021, 30(2): 213-216.
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