[an error occurred while processing this directive] | [an error occurred while processing this directive]
Dermatofibrosarcoma Protuberans:a Systematic Evaluation and Meta-analysis of Efficacy of Postoperative Radiotherapy
Lyu Anqi1, Yin Zheng2, Shan Shijun1, Xie Liangxi3, Wang Qiying4
1Department of Dermatology, Xiang'an Hospital of Xiamen University, Xiamen 361000, China; 2School of Medicine, Xiamen University,Xiamen 361102,China; 3Department of Radiation Oncology, School of Medicine, Xiamen University,Xiamen 361102,China; 4Department of Plastic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
AbstractObjective To evaluate the efficacy of postoperative radiotherapy (PRT) for dermatofibrosarcoma protuberans (DFSP). Methods A systematic review and meta-analysis of articles published before February 23, 2019 were conducted. A total of 655 studies were retrieved consisting of 195 DFSP patients. Among them, 50 cases were assigned into the PRT group and 145 cases in the surgery alone (SA) group. The recurrence rate was statistically compared between two group. Results Meta-analysis showed that the recurrence rate in the PRT group was significantly lower than that in the SA group (8% vs. 24.1%, OR=0.28, P=0.010). The recurrence rate of patients with positive margins in the PRT group was significantly lower compared with that in the SA group (8% vs. 61.5%, P=0.002). The recurrence rate of patients with negative margins in the PRT group had a decreasing trend than that in the SA group (6% vs. 21.6%, P=0.205). Conclusions The recurrence rate of surgery combined with PRT is lower than that of SA. The recurrence rate of patients with positive margins is higher than that of those with negative margins. For patients with positive margins, PRT can decrease the recurrence rate. The recurrence rate trends to decline in patients with negative margins after receiving PRT.
Corresponding Authors:
Wang Qiying, Email:drqqwang@163.com
Cite this article:
Lyu Anqi,Yin Zheng,Shan Shijun et al. Dermatofibrosarcoma Protuberans:a Systematic Evaluation and Meta-analysis of Efficacy of Postoperative Radiotherapy[J]. Chinese Journal of Radiation Oncology, 2021, 30(1): 71-75.
Lyu Anqi,Yin Zheng,Shan Shijun et al. Dermatofibrosarcoma Protuberans:a Systematic Evaluation and Meta-analysis of Efficacy of Postoperative Radiotherapy[J]. Chinese Journal of Radiation Oncology, 2021, 30(1): 71-75.
[1] Lyu A, Wang Q. Dermatofibrosarcoma protuberans:a clinical analysis[J]. Oncol Lett, 2018, 16(2):1855-1862. DOI:10.3892/ol.2018.8802. [2] Sun LM, Wang CJ, Huang CC, et al. Dermatofibrosarcoma protuberans:treatment results of 35 cases[J]. Radiother Oncol, 2000, 57(2):175-181. DOI:10.1016/s0167-8140(00)00228-0. [3] Suit H, Spiro I, Mankin HJ, et al. Radiation in management of patients with dermatofibrosarcoma protuberans[J]. J Clin Oncol, 1996, 14(8):2365-2369. DOI:10.1200/jco.1996.14.8.2365. [4] Marks LB, Suit HD, Rosenberg AE, et al. Dermatofibrosarcoma protuberans treated with radiation therapy[J]. Int J Radiat Oncol Biol Phys, 1989, 17(2):379-384. DOI:10.1016/0360-3016(89)90454-9. [5] Haas RLM, Keus RB, Loftus BM, et al. The role of radiotherapy in the local management of dermatofibrosarcoma protuberans[J]. Eur J Cancer, 1997, 33(7):1055-1060. DOI:10.1016/S0959-8049(97)00026-9. [6] Tsai YJ, Lin PY, Chew KY, et al. Dermatofibrosarcoma protuberans in children and adolescents:clinical presentation, histology, treatment, and review of the literature[J]. J Plast Reconstr Aesthet Surg, 2014, 67(9):1222-1229. DOI:10.1016/j.bjps.2014.05.031. [7] 冯啸,李华. 隆突性皮肤纤维肉瘤49例临床分析[G]. 杭州:2013年全国激光医学学术联合会议暨2013年浙江省医学会整形美容学术年会, 2013. Feng X, Li H. A clinical analysis of 49 cases with dermatofibrosarcoma protuberans[G]. Hangzhou:2013 National Laser Medicine Academic Joint Conference and 2013 Zhejiang Medical Association Plastic Surgery Academic Annual Conference, 2013. [8] 潘蕾. 术后放疗在隆突性皮肤纤维肉瘤治疗中的作用[D]. 杭州:浙江大学, 2007. Pan L. The role of postoperative radiotherapy in the treatment of dermatofibrosarcoma protuberans[D]. Hangzhou:Zhejiang University, 2007. [9] 史振玉, 陈惠彬. 隆起性皮肤纤维肉瘤28例治疗报告[J]. 实用肿瘤杂志, 2003(02):129-130. DOI:10.3969/j.issn.1001-1692.2003.02.019. Shi ZY, Chen HB. The treatment report of 28 cases with protuberant dermatofibrosarcoma[J]. J Pract Oncol, 2003(02):129-130. DOI:10.3969/j.issn.1001-1692.2003.02.019. [2] 张伟,冉晓东,吴克艰,等.20例隆突性皮肤纤维肉瘤临床分析[J]. 四川肿瘤防治, 1999(01):11-12. Zhang W, Ran XD, Wu KJ, et al. The clinical analysis of 20 cases with dermatofibrosarcoma protuberans[J]. Sichuan J Cancer Control, 1999(01):11-12.
2021, Vol. 30 
