肿瘤沉积对ypⅢ期直肠癌患者预后的预测价值

doi:10.3760/cma.j.cn113030-20190821-00338

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Abstract Objective To analyze the predictive effect of tumor deposit(TD) on the prognosis of yp-stage Ⅲ rectal cancer patients,and its effect on postoperative adjuvant chemotherapy benefit. Methods Clinical data of 338 ypⅢ stage rectal cancer patients who received multidisciplinary treatment in Union Medical College Affiliated Hospital of Fujian Medical University from 2007 to 2017 were retrospectively analyzed. All patients were divided into the TD(-) group(n=301) and TD(+) group(n=37). Survival analysis was conducted by Kaplan-Meier method, log-rank test and univariate prognostic analysis. Multivariate prognostic analysis was performed by Cox’s regression model. Results The 5-year overall survival(OS), progress-free survival(PFS), and distant metastasis-free survival(DMFS) in the TD(-) group were significantly higher than those in the TD(+) group(59.3% vs. 42.0%,P=0.001, 79.1% vs. 55.0%,P<0.001, 55.6% vs. 38.0%,P<0.001),whereas no significant difference was observed in local recurrence-free survival(LRFS) between two groups(96.7% vs. 85.5%,P=0.679). Univariate prognostic analysis revealed that the number of TD was not correlated with the prognosis of patients(P=0.923), and postoperative adjuvant chemotherapy exerted no significant effect on the prognosis of patients in two groups(P=0.103). In multivariate analysis, TD was associated with worse OS(HR=2.343,95%CI:1.257-4.363, P=0.007). Conclusions For patients with ypⅢ stage rectal cancer undergoing multidisciplinary treatment, the prognosis of patients with TD is even worse. TD is an independent predictor for survival. No benefit can be obtained from postoperative adjuvant chemotherapy regardless of the presence or absence of TD.

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	Articles by authors
	Zhu Qiaoping
	Li Anchuan
	Xu Benhua

Key words： Tumor deposit rectal neoplasm/multidisciplinary treatment Prognosis

Received: 21 August 2019

Corresponding Authors: Xu Benhua, Email:benhuaxu@ 163.com;Li Anchuan, Email:lianchuan@outlook.com

Cite this article:

Zhu Qiaoping,Li Anchuan,Xu Benhua. Predictive value of tumor deposit for the prognosis of patients with yp-stage Ⅲ rectal cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(1): 47-53.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20190821-00338 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I1/47

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