盆腔淋巴结转移性前列腺癌大分割调强放疗联合内分泌治疗疗效分析

doi:10.3760/cma.j.cn113030-20200110-00014

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Abstract Objective To investigate the efficacy and prognosis of hypofractionated intensity-modulated radiation therapy combined with hormonal therapy in the treatment of pelvic lymph node metastatic prostate cancer. Methods Clinical data of 42 IVA prostate cancer patients who received hypofractionated intensity-modulated radiation therapy combined with hormonal therapy in Cancer Hospital of Chinese Academy of Medical Sciences between 2006 and 2018 were retrospectively analyzed. The total irradiation doses to the prostate and seminal vesicles were 67.5Gy/25f,2.7Gy/f. The prophylactic irradiation doses to the pelvic lymph nodes were 45-50Gy with a daily fraction dose of 1.8-2.0Gy. Thirty-three patients with residual lymph nodes were boosted to 60.0-67.5Gy for the residual area, 2.4-2.7Gy/f. Androgen deprivation therapy included surgical castration or luteinizing hormone-releasing hormone agonists combined with antiandrogens. Survival rate was calculated using Kaplan-Meier method. The differences between two groups were analyzed by log-rank test. Prognostic factors were identified by univariate and multivariate analyses. Results The median follow-up was 65.5 months (range, 5 to 150 months). The 5-year and 10-year failure-free survival (FFS) rates in the whole group were 67% and 45%, respectively. No clinical recurrence was observed in the irradiation field. The 5-year and 10-year prostate cancer-specific survival/overall survival (PCSS/OS) rates were 85% and 60%, respectively. Gleason score (≥8 and<8) and duration of hormonal therapy impacted the FFS (both P<0.05). The duration of hormonal therapy was an independent prognostic factor for PCSS/OS (P=0.003). Conclusions Hypofractionated intensity-modulated radiotherapy combined with hormonal therapy yields optimistic clinical efficacy in the treatment of pelvic lymph node metastatic prostate cancer. Gleason score (≥8 and <8) and duration of hormonal therapy are critical prognostic factors.

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	Articles by authors
	Yao Lihong
	Liu Yueping
	Li Yexiong
	Wang Shulian
	Jin Jing
	Fang Hui
	Song Yongwen
	Tang Yu
	Tang Yuan
	Yang Yong
	Qi Shunan
	Chen Bo
	Lu Ningning
	Yu Zihao

Key words： Prostate meoplasm/intensity-modulated radiotherapy Intensity-modulated,hypofrac-tionated Prognosis

Received: 10 January 2020

Corresponding Authors: Liu Yueping, Email:yuepingliu8@hotmail.com;Li Yexiong, Email:yexiong12@163.com

Cite this article:

Yao Lihong,Liu Yueping,Li Yexiong et al. Efficacy analysis of hypofractionated intensity-modulated radiation therapy combined with hormonal therapy for pelvic lymph node metastatic prostate cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(1): 42-46.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20200110-00014 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I1/42

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