维吾尔族妇女局部晚期宫颈鳞癌外周血T细胞亚群与临床特征和预后关系

doi:10.3760/cma.j.cn113030-20200923-00476

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Abstract Objective To observe the relationship between peripheral blood T cell subsets and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma in Xinjiang. Methods A total of 185 patients pathologically diagnosed with stage ⅡB-IVA cervical squamous cell carcinoma admitted to Cancer Hospital Affiliated to Xinjiang Medical University from January 2015 to December 2018 were selected. The relationship between T cell subsets in peripheral venous blood and clinical characteristics and prognosis was analyzed. Results CD⁺₄ T cells, CD⁺₈ T cells and CD⁺₄/CD⁺₈ T cell ratio were significantly correlated with clinical stage, tumor diameter and body mass index (BMI)(all P<0.05). The later Federation International Association of Gynecology and Obstetrics (FIGO) tumor stage, the larger the tumor diameter, the higher the BMI, and the higher the CD⁺₈ T cells and the lower the CD⁺₄ T cell and CD⁺₄/CD⁺₈ T cell ratio. The count of CD⁺₄ T cells was decreased in patients with lymph node metastasis. Cox’s univariate analysis showed that FIGO stage, age, lymph node metastasis, tumor diameter, BMI, CD⁺₄ T cells, CD⁺₈ T cells, CD⁺₄/CD⁺₈ T cell ratio and treatment methods were the important factors affecting the overall survival (OS). Multivariate analysis showed that BMI, treatment method, CD⁺₄T cells and tumor diameter were the independent prognostic factors affecting OS (all P<0.05). Conclusions The level of T cell subsets in peripheral blood of Uygur cervical cancer patients is out of balance. CD⁺₄T cells, CD⁺₈ T cells and CD⁺₄/CD⁺₈ T cell ratio are associated with FIGO stage, tumor diameter and BMI, and CD⁺₄T cells are correlated with lymph node metastasis. BMI, treatment method, tumor diameter and CD⁺₄ T cell are the independent prognostic factors affecting the OS of patients with cervical cancer.

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	Guo Yuping
	Gulina·Kulban
	Wang Ruozheng

Key words： Cervical cancer CD⁺₄ T cell CD⁺₈ T cell CD⁺₄/CD⁺₈ T cell ratio Prognosis

Received: 23 September 2020

Fund:National Natural Science Foundation of China (U1603282);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2018PT31050)

Corresponding Authors: Wang Ruozheng, Email:Wrz8526@vip.163.com

Cite this article:

Guo Yuping,Gulina·Kulban,Wang Ruozheng. Relationship between T cell subsets in peripheral blood and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2020, 29(12): 1064-1069.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20200923-00476 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I12/1064

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