早期乳腺癌保乳术后瘤床同步整合与瘤床后程补量IMRT研究

doi:10.3760/cma.j.cn113030-20191212-00515

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Abstract Subject To compare the irradiation-induced injury and clinical efficacy between SIB-IMRT and LB-IMRT for early-stage breast cancer after breast-conserving surgery. Methods From November 2002 to February 2012, 353 early breast cancer patients who underwent IMRT after breast-preserving surgery at Shandong Cancer Hospital were selected, of whom 218 patients receiving SIB-IMRT and 135 patients receiving LB-IMRT.The prescription dose of the SIB-IMRT group was the ipsilateral breast (PTVb )1.8-1.9 Gy, 27-28 times, and concurrent tumor bed (PTVt) 2.15-2.3 Gy, 27-28 times. In the LB-IMRT group, the prescription dose was PTVb 2.0 Gy, 25 times, followed by PTVt boost 2.0 Gy, 5-8 times. Results The median follow-up time was 92 months. The excellent, good, fair, and poor cosmetic results in the SIB-IMRT and LB-IMRT groups were 10.1% and 12.6%, 85.8% and 80.7%, 3.7% and 5.2%, 0.5%, and 0.7%, respectively (P=0.731). The 5-year locoregional recurrence rates (LRRs) in the SIB-IMRT and LB-IMRT groups were 3.21% and 5.93% and the 10-year LRRs were 4.13% and 6.67%, respectively (P=0.209, 0.280). The 3-, 5-, 8-, and 10-year overall survival rate in the SIB-IMRT and LB-IMRT groups were 97.7% and 97.8%, 96.3% and 95.2%, 94.9% and 92.0%, 93.6% and 90.3%, respectively (P=0.288). The 3-, 5-, 8-, and 10-year disease-free survival in the SIB-IMRT and LB-IMRT groups were 95.4% and 93.8%, 91.8% and 87.7%, 89.9% and 84.1%, 89.0% and 82.1%, respectively (P=0.160). Conclusion There is no significant difference in the cosmetic effect, local control rate, and survival rate between SIB-IMRT and LB-IMRT after breast-preserving surgery in patients with early-stage breast cancer. SIB-IMRT is a safe and feasible treatment.

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	Xu Min
	Wang Suzhen
	Wang Wei
	Shao Qian
	Zhang Yingjie
	Li Fengxiang
	Li Jianbin

Key words： Breast neoplasm/postoperative radiotherapy Radiotherapy, intensity-modulated Radiotherapy, simultaneous integrated boost Radiotherapy, late-course boost Cosmetic effect Prognosis

Received: 12 December 2019

Corresponding Authors: Li Jianbin, Email:lijianbin0708@126.com

Cite this article:

Xu Min,Wang Suzhen,Wang Wei et al. Comparison of clinical efficacy between simultaneous integrated boostintensity-modulated radiotherapy (SIB-IMRT) and late-course boost intensity-modulated radiotherapy (LB-IMRT) for early-stage breast cancer after breast-conserving surgery[J]. Chinese Journal of Radiation Oncology, 2020, 29(11): 948-953.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20191212-00515 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I11/948

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