胶质瘤离子放疗的剂量学研究

doi:10.3760/cma.j.cn113030-20190212-00048

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Abstract Objective To investigate the dosimetric difference between glioma patients treated by particle (proton+carbon ion) and photon radiotherapy. Methods Twelve previously-treated glioma patients were selected, and given with the same total dose of 60.00 Gy [RBE]. Two types of planning target volumes (PTVs) including PTV-ion and PTV-photon were expended from clinical target volumes according to range uncertainty and patient setup errors. Based on PTV-ion, proton plans with sequential carbon ion boost (particle plan) were created. Following the same prescription, two types of photon intensity-modulated radiotherapy (IMRT) plans were established to achieve similar target coverage and compare the dose of organs at risk. Results Target coverages of three types of plans had no statistical difference (all P>0.05). The median integral dose of normal brain of all patients receiving particle plan was merely 44.90% of the minimum number from photon plans (P<0.001). Compared with the minimum number from photon plans, particle radiotherapy decreased the mean dose of brain stem[(6.83±6.22) Gy[RBE] vs. (15.10±10.11) Gy[RBE], P=0.001)], the maximum dose of chiasm[(47.76±20.80) Gy[RBE] vs. (49.59±20.52) Gy[RBE], P=0.009)] and the mean dose of contralateral hippocampus (0.26±9.08) Gy[RBE] vs. (16.28±11.14) Gy[RBE], P=0.002), respectively. Conclusions Particle radiotherapy can achieve similar target coverage while maintaining lower normal tissue doses to the photon radiotherapy. Photon planion can increase the doses to adjuvant normal tissues.

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	Lu Yan
	Wang Weiwei
	Xing Ying
	Gao Jing
	Kong Lin
	Lu Jiade

Key words： Brain neoplasm/radiotherapy Radiotherapy, particle Radiotherapy, photon Dosimetry

Received: 12 February 2019

Fund:Join Breakthrough Project for New Frontier Technologies of the Shanghai Hospital Development Center (SHDC12016120)

Corresponding Authors: Wang Weiwei, Email:weiwei.wang@sphic.org.cn

Cite this article:

Lu Yan,Wang Weiwei,Xing Ying et al. Dosimetric study of particle radiotherapy for glioma patients[J]. Chinese Journal of Radiation Oncology, 2020, 29(10): 866-871.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20190212-00048 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I10/866

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