乳腺导管原位癌与导管原位癌伴微浸润的临床比较

doi:10.3760/cma.j.issn.1004-4221.2020.03.007

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Abstract Objective To analyze the differences in the treatment patterns,clinical characteristics,treatment outcomes and prognostic factors between breast cancer patients with ductal carcinoma in situ (DCIS) and ductal carcinoma in situ with microinvasion (DCIS-MI).Methods Clinical data of 866 female patients including 631 DCIS cases and 235 DCIS-MI cases treated in our institution between 1999 and 2013 were retrospectively analyzed. The local control (LC),disease-free survival (DFS) and overall survival (OS) rates were calculated by Kaplan-Meier survival analysis. The prognostic factors were identified by Log-rank test. Results Similar LC,DFS and OS rates were obtained between two groups (all P>0.05). The univariate analysis demonstrated that Her-2-positive patients had worse OS and DFS than Her-2-negative counterparts. Patients undergoing breast-conserving surgery without radiotherapy had lower LC and DFS rates compared with those receiving radical mastectomy. Conclusions DCIS and DCIS-MI patients have similar clinical prognosis in terms of OS,LC and DFS. Her-2 positive is an unfavorable prognostic factor for DFS and OS. The LC and DFS rates in the breast-conserving surgery alone group are worse than those in the mastectomy group.

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	Articles by authors
	Liu Weixin
	Wang Shulian
	Tang Yu
	Jing Hao
	Wang Jianyang
	Zhang Jianghu
	Jin Jing
	Song Yongwen
	Wang Weihu
	Liu Yueping
	Fang Hui
	Ren Hua
	Qi Shunan
	Lu Ningning
	Tang Yuan
	Li Ning
	Li Yexiong

Key words： Breast ductal carcinoma in situ Breast ductal carcinoma in situ with microinvasion Breast neoplasm/radiotherapy Breast neoplasm/surgery Prognosis

Received: 25 February 2019

Fund:National Key Research and Development Project (2016YFC0904600);Capital Clinical Characteristic Applied Research (Z171100001017116)

Corresponding Authors: Wang Shulian,Email:wsl20040118@yahoo.com;Tang Yu,Email:tangyu.pumc@gmail.com

Cite this article:

Liu Weixin,Wang Shulian,Tang Yu et al. Clinical comparison between ductal carcinoma in situ and ductal carcinoma in situ with microinvasion[J]. Chinese Journal of Radiation Oncology, 2020, 29(3): 187-192.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2020.03.007 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I3/187

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