鼻咽癌乏氧区MRI影像组学特征分析

doi:10.3760/cma.j.issn.1004-4221.2019.12.010

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Abstract Objective To analyze the magnetic resonance imaging (MRI) radiomic performance of hypoxic area in nasopharyngeal carcinoma patients, aiming to provide a reference for identification and analysis of hypoxic area. Methods The MRI-T1, MRI-T2, MRI-T1+ and PET/CT images of 32 patients initially diagnosed with nasopharyngeal carcinoma were retrospectively analyzed. The gross tumor volume (GTV) of nasopharynx was countoured and the hypoxic areas (GTV-H) were identified by ¹⁸F-FMISO-PET images. The non-hypoxic areas (GTV-NH) were defined as the rest of areas removed GTV-H from GTV. The radiomic features of GTV-H and GTV-NH were extracted and compared. Results The average volume of GTV-H and GTV-NH was (10.92±11.02) cm³ and (7.21±5.70) cm³,respectively. The maximum rate of change was 46% for intensity direct-global min (ID-GM) on MRI-T1(P<0.05,AUC>0.7 and Youden index>0.5). The average rate of change was 136% for long run emphasis (LRE),long run high gray level emphasis (LRHGLE) and long run low gray level emphasis (LRLGLE) on MRI-T2(P<0.05,AUC>0.7 and Youden index>0.5). The high change rates was greater than 90% on MRI-T1+(P<0.05,AUC>0.7 and Youden index>0.5) for ID-GM,LRE,LRHGLE and LRLGLE. Conclusions The hypoxic area of tumor target can be reflected by MRI radiomics on T1/T2/T1+. Quantifying and tracking the variations of these features can bring benefit to recognize the hypoxic area of nasopharyngeal carcinoma tumor target.

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	Articles by authors
	Kong Xudong
	Li Tengxiang
	Gong Guanzhong

Key words： Nasopharyngeal neoplasm hypoxic area Radiomics Hypoxic area identification

Received: 11 June 2018

Cite this article:

Kong Xudong,Li Tengxiang,Gong Guanzhong. Analysis of MRI radiomic features of hypoxic area in nasopharyngeal carcinoma patients[J]. Chinese Journal of Radiation Oncology, 2019, 28(12): 924-927.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.12.010 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I12/924

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