放疗联合免疫检查点抑制剂治疗Ⅲ期不可切除非小细胞肺癌研究进展

doi:10.3760/cma.j.issn.1004-4221.2019.11.016

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Abstract Chemoradiation has been the standard treatment of stage Ⅲ unresectable non-small cell lung cancer (NSCLC) for a long period of time. However,the clinical efficacy of chemoradiation has not been significantly improved in recent two decades. In the past 2-3 years,the role of immune-checkpoint inhibitors in metastatic NSCLC has been persistently strengthened. Moreover,the synergistic effect between radiotherapy and immune-checkpoint blockade has been conformed in pre-clinical and clinical studies. Recent clinical trials have demonstrated that the combination of radiotherapy and immune-checkpoint blockade has been proven to be more effective in the treatment of stage Ⅲ unresectable NSCLC. In this article, the latest clinical studies since 2017 regarding the application value of this combined treatment of stage Ⅲ unresectable NSCLC were summarized.

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	Articles by authors
	Li Rutian
	Zhu Zhengfei
	Wang Lifeng
	Yan Jing
	Yan Yingtzu
	Liu Baorui

Key words： Lung neoplasm/radiotherapy Immune-checkpoint blockade Research progress

Received: 15 November 2018

Fund:National Natural Science Foundation of China (81672398);5th Group of “333 Talent Project” of Jiangsu Province ((2016)Ⅲ-0119);14th Group of “Six Talent Peak” Project in Jiangsu Province (YY-068);Medical Youth Talent Project of Jiangsu Province (QNRC2016044)

Corresponding Authors: Liu Baorui,Email:baoruiliu@nju.edu.cn

Cite this article:

Li Rutian,Zhu Zhengfei,Wang Lifeng et al. Research progress on application of the combination of radiotherapy and immune-checkpoint blockade in treatment of stage Ⅲ unresectable non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(11): 872-875.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.11.016 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I11/872

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