[an error occurred while processing this directive] | [an error occurred while processing this directive]
Preliminary study of the relationship between the expression of NRAGE and the therapeutic effect of radiotherapy in patients with esophageal squamous cell carcinoma
Tian Zhesen1, Liu Huizhi1, Zhou Huandi1, 2, Zhang Yufeng1, Zhang Ge1, Gai Xiaohui1, Liu Chunmei1, Xue Xiaoying1
1Department of Radiotherapy,Second Hospital of Hebei Medical University,Shijiazhuang 050000,China; 2Central Laboratory of the Second Affiliated Hospital of Hebei Medical University,Shijiazhuang 050000,China
AbstractObjective To detect the expression of NRAGE protein in esophageal squamous cell carcinoma and investigate the relationship between NRAGE and therapeutic effect of radiotherapy. Methods The expression level of NRAGE in 44 patients with esophageal squamous cell carcinoma was evaluated by immunohistochemistry and statistically analyzed along with clinical data by using multivariate analysis using Cox regression model. Results The overall expression level of NRAGE protein in esophageal squamous cell carcinoma (P=0.025) and the expression level of NRAGE nuclear protein (P=0.008) were negatively correlated with short-term efficacy. In terms of the overall expression level of NRAGE protein, the 3-year survival rates in the strongly positive group and the positive weakly positive group were 16% and 36%(P=0.198). As for the expression of NRAGE nuclear protein, the 3-year survival rates in the strongly positive group and the positive+ weakly positive group were 0% and 41%(P<0.001). Multivariate analysis using Cox regression model demonstrated that as for the expression of NRAGE nuclear protein, the risk of death in the strongly positive group was significantly higher than those in the positive+ weakly positive group (P=0.002). Conclusion The overall expression level of NRAGE protein in the esophageal cancer is negatively correlated with the short-term efficacy of radiotherapy, whereas it is not correlated with long-term survival rate. The strongly positive expression level of NRAGE nuclear protein is negatively correlated with the short-term efficacy of radiotherapy and the long-term survival rate, prompting that NRAGE may be a molecular indicator for predicting radiation resistance and even the efficacy of radiotherapy for esophageal squamous cell carcinoma
Tian Zhesen,Liu Huizhi,Zhou Huandi et al. Preliminary study of the relationship between the expression of NRAGE and the therapeutic effect of radiotherapy in patients with esophageal squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(10): 746-748.
Tian Zhesen,Liu Huizhi,Zhou Huandi et al. Preliminary study of the relationship between the expression of NRAGE and the therapeutic effect of radiotherapy in patients with esophageal squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(10): 746-748.
[1] Masuda Y, Sasaki A, Shibuya H, et al. Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function[J]. J Biol Chem, 2001,276(7):5331-5338. DOI:10.1074/jbc. M008590200. [2] Xue XY, Liu ZH, Jing FM, et al. Relationship between NRAGE and the radioresistance of esophageal carcinoma cell line TE13R120[J]. Chin J Cancer, 2010,29(10):900-906. [3] Zhou H, Zhang G, Xue X, et al. Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells[J]. Tumour Biol, 2016,37(7):8741-8752. DOI:10.1007/s13277-015-4747-6. [4] 中国非手术治疗食管癌临床分期专家小组. 非手术治疗食管癌的临床分期标准(草案)[J]. 中华放射肿瘤学杂志,2010,19(3):179-180. DOI:10.3760/cma.j.issn.1004-4221.2010.03.001. [5] Axiotis CA, Monteagudo C, Merino MJ, et al. Immunohistochemical detection of P-glycoprotein in endometrial adenocarcinoma[J]. Am J Pathol, 1991,138(4):799-806. [6] Ginos MA, Page GP, Michalowicz BS, et al. Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck[J]. Cancer Res, 2004,64(1):55-63.
2019, Vol. 28 
