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Effect of tumor length on clinical stage for non-operative esophageal squamous cell carcinoma patients—multicenter retrospective data analysis (3JECROG R-01D)
Zhou Zhiguo1, Wang Xin2, Wang Lan1, Chen Junqiang3, Zhang Wencheng4, Wang Xiaomin5, Ge Xiaolin6, Shen Wenbin1, Hu Miaomiao7, Yuan Qianqian7, Xu Yonggang8, Hao Chongli7, Qie Shuai9, Lu Na10, Pang Qingsong4, Wang Ping4, Zhao Yidian5, Sun Xinchen6, Zhang Kaixian7, Li Gaofeng8, Li Ling7, Liu Miaoling9, Wang Yadi10, Li Chen2, Zhu Shuchai1, Xiao Zefen2, Han Chun1, Qiao Xueying1
1Department of Radiation Oncology,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China; 2Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences ( CAMS ) and Peking Union Medical College (PUMC),Beijing 100021,China; 3Department of Radiation Oncology,Fujian Cancer Hospital/Fujian Medical University Cancer Hospital,Fuzhou 350014,China; 4Department of Radiation Oncology,Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center for Cancer,Tianjin 300060,China; 5Department of Radiation Oncology,Anyang Cancer Hospital,Anyang 455000,China; 6Department of Radiation Oncology,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China; 7Department of Oncology,Tengzhou Central People′s Hospital,Tengzhou 277599,China; 8Department of Radiation Oncology,Beijing Hospital,National Center of Gerontology,Beijing 100730,China; 9Department of Radiation Oncology,Affiliated Hospital of Hebei University,Baoding 071000,China; 10Department of Radiation Oncology,PLA Army General Hospital,Beijing 100700,China
AbstractObjective To retrospectively analyze the effect of tumor length on the prognosis in stage Ⅱ/Ⅲ esophageal squamous cell carcinoma (ESCC) patients treated with definitive radiotherapy and to evaluate the role of tumor length in clinical stage for non-operative ESCC patients. Methods The data of 2 086 ESCC patients who were treated with definitive radiotherapy from 2002 to 2016 in 10 hospitals (3JECROG) were analyzed. The effect of tumor length on overall survival (OS) was analyzed and stratified analysis of tumor length was done in different stages of ESCC. Results The median OS and median progression-free survival (PFS) time of the whole group were 25.6 months and 18.2 months respectively. The Cox multivariate analysis showed that treatment mode,age,clinical stage and tumor length were independent prognostic factors. The median,1-,3-,and 5-year OS were 28.9 months,77.3%,45.0%,and 36.3% versus 21.9 months,69.9%,37.9%,and 28.1% for patients with ≤5 cm and patients>5 cm respectively (P<0.05). For stage Ⅱ patients,the median OS were 42.1 and 38.9 months respectively in ≤5 cm group and>5 cm group (P=0.303). And for stage Ⅲ patients,the median OS were 23.9 and 19.3 months respectively in ≤5 cm group and>5 cm group (P<0.001). The median OS with N1was 24.1 and 18.4 months,respectively in≤5 cm group and>5 cm group (P<0.001). Conclusions The tumor length was an independent prognostic factor for stage Ⅱ/Ⅲ patients treated definitive radiotherapy. The tumor length may be helpful in clinical staging of ESCC,especially for stage Ⅲ and N1.
Corresponding Authors:
Han Chun, Email:hanchun2006@126.com;Qiao Xueying, Email:xueying_qiao@126.com
Cite this article:
Zhou Zhiguo,Wang Xin,Wang Lan et al. Effect of tumor length on clinical stage for non-operative esophageal squamous cell carcinoma patients—multicenter retrospective data analysis (3JECROG R-01D)[J]. Chinese Journal of Radiation Oncology, 2019, 28(7): 490-494.
Zhou Zhiguo,Wang Xin,Wang Lan et al. Effect of tumor length on clinical stage for non-operative esophageal squamous cell carcinoma patients—multicenter retrospective data analysis (3JECROG R-01D)[J]. Chinese Journal of Radiation Oncology, 2019, 28(7): 490-494.
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2019, Vol. 28 
