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Superiority of breast-conserving surgery plus radiotherapy versus modified mastectomy in patients with stage Ⅰ breast cancer:a propensity score-matching analysis
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences ( CAMS ) and Peking Union Medical College ( PUMC),Beijing 100021,China
AbstractObjective To compare the clinical efficacy between breast-conserving surgery (BCS) plus radiotherapy (RT) and modified mastectomy in patients with stage Ⅰ breast cancer in clinical setting. Methods Clinical data of 6137 patients diagnosed with pT1-2N0 breast cancer from 1999 to 2014 were retrospectively reviewed. Among them, 1296 patients received BCS plus RT (BCS group) and 4841 cases underwent modified mastectomy alone (modified mastectomy group). Kaplan-Meier analysis was used for survival analysis. Log-rank test, single factor analysis and Cox’s proportional hazards regression model were performed. The results were further confirmed with the propensity score-matching (PSM) method.Results Within a median follow-up period of 55.2 months (range,1-222 months),the 5-year locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS),disease-free survival (DFS) and overall survival (OS) were 96.3%, 93.7%, 91.9% and 96.9%, respectively. In the BCS plus RT group, the 5-year DMFS (96.9% vs. 92.9%, P<0.001),DFS (94.9% vs. 91.2%, P=0.005) and OS (99.1% vs. 96.4%,P=0.001) were significantly higher than those in the mastectomy group.Multivariate analysis revealed that postoperative RT was an influencing factor of DMFS (P=0.003,HR=0.621;95%CI:0.455–0.849) and OS (P=0.036;HR=0.623;95%CI:0.401–0.969). For 1252 pairs of patients matched by PSM, the 5-year OS (99.1% vs. 96.1%,P=0.001), DMFS (97.0% vs. 92.2%,P<0.001) and DFS (95.3% vs. 90.2%,P=0.001) in the BCS plus RT group were significantly higher compared with those in the mastectomy group. Conclusion The long-term clinical prognosis of patients with stage Ⅰ breast cancer in the BCS plus RT group is better than that in the mastectomy group. BCS plus RT should be recommended for patients with stage Ⅰ breast cancer.
Fund:National Natural Science Foundation of China (81602168);National Key Research& Development Program Project (2016YFC0904600);Medical and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences (2017-I2M-2-005)
Wang Jianyang,Wang Shulian,Song Yongwen et al. Superiority of breast-conserving surgery plus radiotherapy versus modified mastectomy in patients with stage Ⅰ breast cancer:a propensity score-matching analysis[J]. Chinese Journal of Radiation Oncology, 2019, 28(4): 286-291.
Wang Jianyang,Wang Shulian,Song Yongwen et al. Superiority of breast-conserving surgery plus radiotherapy versus modified mastectomy in patients with stage Ⅰ breast cancer:a propensity score-matching analysis[J]. Chinese Journal of Radiation Oncology, 2019, 28(4): 286-291.
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2019, Vol. 28 
