乳腺导管内原位癌治疗趋势和预后单中心分析

doi:10.3760/cma.j.issn.1004-4221.2019.02.004

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Abstract Objective To analyze the changes in treatment patterns,clinical characteristics,treatment outcomes and prognostic factors of ductal carcinoma in situ (DCIS). Methods Clinical data of 617 female patients admitted to our institution between 2000 and 2013 were retrospectively analyzed. Kaplan-Meier survival analysis was adopted to calculate the local control (LC),disease-free survival (DFS) and overall survival (OS) rates. Log-rank test was utilized to identify the prognostic factors. Results Along the number of DCIS patients was gradually increased year by year,the proportion of breast conservative surgery was also elevated. However,mastectomy remained the primary surgical method. A total of 374 patients underwent mastectomy,160 cases received breast conservative surgery plus radiotherapy and 83 underwent breast conservative surgery alone. Postoperatively,366 patients (83.6%) with positive hormone receptor received hormone therapy and 45 patients (7.3%) underwent chemotherapy. The median follow-up time was 47 months. The 5-year LC,DFS and OS rates were 98.4%,97.5% and 98.9%,respectively. Univariate analysis demonstrated that Her-2-positive patients obtained worse OS (P=0.019). Although mastectomy group had more adverse factors compared with breast conservative surgery with or without radiotherapy groups,similar survival results were obtained among three groups. Mastectomy yielded better LC and DFS compared with breast conservative surgery alone. Conclusions DCIS patients obtain favorable clinical prognosis between the breast conservative surgery and mastectomy groups. The LC rate in the mastectomy group is better than that in the breast conservative surgery group.

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	Articles by authors
	Liu Weixin
	Wang Shulian
	Song Yongwen
	Tang Yu
	Jing Hao
	Wang Jianyang
	Zhang Jianghu
	Jin Jing
	Wang Weihu
	Liu Yueping
	Fang Hui
	Ren Hua
	Qi Shunan
	Lu Ningning
	Tang Yuan
	Li Ning
	Li Yexiong

Key words： Breast ductal carcinoma in situ Radiotherapy Surgery Prognosis

Received: 28 April 2018

Fund:National Key Research and Development Projects (2016YFC0904600);Capital Clinical Characteristic Applied Research (Z171100001017116)

Corresponding Authors: Wang Shulian,Email:wsl20040118@yahoo.com;Song yongwen,Email:Email:song21yongwen@aliyun.com

About author:: National Key Research and Development Projects (2016YFC0904600);Capital Clinical Characteristic Applied Research (Z171100001017116)

Cite this article:

Liu Weixin,Wang Shulian,Song Yongwen et al. Treatment trends and prognosis of breast ductal carcinoma in situ:a single center analysis[J]. Chinese Journal of Radiation Oncology, 2019, 28(2): 96-101.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.02.004 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I2/96

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