口服营养补充对鼻咽癌放化疗患者近期营养状况及治疗耐受性影响

doi:10.3760/cma.j.issn.1004-4221.2019.08.004

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Abstract

Objective To explore the impact of oral nutritional supplements in the local advanced nasopharyngeal carcinoma patients receiving chemoradiotherapy. Methods From 2016 to 2018, we prospectively collected 114 patients into our study, including intervention group (n=58) and control group (n=56).Patients in the intervention group were given oral nutritional supplements from the beginning of radiotherapy, while the control group patients were receiving usual diet care. We collected data of weight, hematological index and nutrition related information before, during and after treatments. Results All patients experienced weight loss during radiotherapy. The declining trend was more obvious in intervention group but with no statistical difference (P>0.05). Radiotherapy interruption was lower, completion rateof2 cycles of concurrent chemotherapy was higher(78% vs 64%, P=0.02)and level of total serum protein and albumin was more stable (P=0.003,0.001) in the intervention group. No difference was found in acute toxicities between the two groups (P>0.05). During the treatment period, the nutrition risk screening score declined, more patients with NRS 2002 ≥3 in the control group than the intervention group (P<0.05), while no statistically significant difference was found in PG-SGA between the two groups (P>0.05). Conclusions Oral nutritional supplements can improve treatment tolerance and keep the stability of serum protein level, nevertheless, it has no obvious advantage in maintenance of weight and short-term nutritional status

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	Articles by authors
	Chen Yuanyuan
	Huang Shuang
	Hu Qiaoying
	Hua Yonghong
	Jiang Feng
	Cao Caineng
	Piao Yongfeng
	Jin Ting
	Jin Qifeng
	Tang Qiu
	Chen Xiaozhong
	Chen Ming
	Tian Ye

Key words： Nasopharyngeal neoplasms/chemoradiotherapy Nutrition supplement Treatment tolerance

Received: 15 June 2019

Fund:

Zhejiang Medical and Health General Research Program (surface)(20182448552);Jiangsu Key Research and Development Program (BL2018657);Zhejiang Medical and Health Science and Technology Program (2015KYA032)

Corresponding Authors: Tian Ye,Email:dryetian@126.com;Chen Ming, Email:chenming@zjcc.org.cn

Cite this article:

Chen Yuanyuan,Huang Shuang,Hu Qiaoying et al. Effects of oral nutritional supplement on short-term nutritional status and treatment tolerance in locally advanced nasopharyngeal carcinoma patients receiving chemoradiotherapy[J]. Chinese Journal of Radiation Oncology, 2019, 28(8): 575-579.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2019.08.004 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2019/V28/I8/575

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