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Nutritional treatment of radiotherapy-induced mucosal injury
Wang Shuan1, Wang Kongcheng2, Yuan Li1, Xu Ping1, Yan Jing2
1Department of Clinical Nutrition, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China; 2Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China
Abstract Mucosal injury is the most common complication of radiotherapy for head and neck neoplasms. The relevant symptoms include oral pain, dysphagia, decreased diet intake, and secondary infection, which can lead to the interruption of treatment and even affect the clinical efficacy and quality of life. Wound repair depends on nutrition supply. Inappropriate nutrition plan may affect the healing process. Therefore, proper nutritional strategy plays a pivotal role in promoting the healing of mucosal injury. Based on current researches on radiotherapy-induced mucosal injury and the effect of nutrients on wound healing, the epidemiology, pathophysiology, clinical manifestations and nutritional therapy for radiotherapy-induced mucosal injury were reviewed, aiming to provide references for clinical practice.
Corresponding Authors:
Yan Jing, Email:yj20030610@sina.com
Cite this article:
Wang Shuan,Wang Kongcheng,Yuan Li et al. Nutritional treatment of radiotherapy-induced mucosal injury[J]. Chinese Journal of Radiation Oncology, 2019, 28(7): 555-558.
Wang Shuan,Wang Kongcheng,Yuan Li et al. Nutritional treatment of radiotherapy-induced mucosal injury[J]. Chinese Journal of Radiation Oncology, 2019, 28(7): 555-558.
[1]Lalla RV,Sonis ST,Peterson DE. Management of oral mucositis in patients who have cancer[J]. Dent Clin North Am,2008,52(1):61-77. DOI:10.1016/j.cden.2007.10.002. [2]Mallick S,Benson R,Rath GK. Radiation induced oral mucositis:a review of current literature on prevention and management[J]. Eur Arch Oto-Rhino-Laryngol,2016,273(9):2285-2293. DOI:10.1007/s00405-015-3694-6. [3]Peterson DE,Boersdoets CB,Bensadoun RJ,et al. Management of oral and gastrointestinal mucosal injury:ESMO clinical practice guidelines for diagnosis,treatment,and follow-up[J]. Ann Oncol,2015,Suppl 5:v139-51. DOI:10.1093/annonc/mdv202. [4]Sonis ST. The pathobiology of mucositis[J]. Nat Rev Cancer,2004,4(4):277-284. DOI:10.1038/nrc1318. [5]Massaro P,Corbella F,Liberto RDI,et al. Late oral mucosa alterations after radiotherapy for head and neck cancer assessed by exfoliative cytology[J]. Anticancer Res,2014,34(2):837-44. DOI:10.1093/annonc/mdt567. [6]Müller-Richter U,Betz C,Hartmann S,et al. Nutrition management for head and neck cancer patients improves clinical outcome and survival[J]. Nut Res,2017,48(1):1-8. DOI:10.1016/j.nutres.2017.08.007. [7]Du XJ, Tang LL, Mao YP,et al.Value of the prognostic nutritional index and weight loss in predicting metastasis and long-term mortality in nasopharyngeal carcinoma[J]. J Trans Med,2015,13:364. DOI:10.1186/s12967-015-0729-0. [8]Vangelov B,Smee RI. Clinical predictors for reactive tube feeding in patients with advanced oropharynx cancer receiving radiotherapy±chemotherapy[J]. Eur Arch Oto-Rhino-Laryngol,2017,274(10):3741-3749. DOI:10.1007/s00405-017-4681-x. [9]Saeki H,Nakashima Y,Kudou K,et al. Neoadjuvant chemoradiotherapy for patients with cT3/Nearly T4 esophageal cancer:is sarcopenia correlated with postoperative complications and prognosis?[J]. World J Surg, 2018,42(9):2894-2901. DOI:10.1007/s00268-018-4554-5. [10]Zhao JZ,Zheng H,Li LY,et al. Predictors for weight loss in head and neck cancer patients undergoing radiotherapy:a systematic review[J]. Cancer Nur,2015,38(6):E37-45. DOI:10.1097/NCC.0000000000000231. [11]Mtaweh H,Tuira L,Floh AA,et al. Indirect calorimetry:history,technology,and application[J]. Front Pediatr.2018 Sep 19;6:257. DOI:10.3389/fped.2018.00257.eCollection 2018. [12]中国抗癌协会肿瘤营养与支持治疗专业委员会. 中国肿瘤营养治疗指南[M]. 北京:人民卫生出版社,2015. China anticancer association oncology nutrition and support therapy professional committee. Guidelines for the treatment of tumor nutrition in China[M]. Beijing:People′s medical publishing housecommittee,2015. [13]CSCO肿瘤营养治疗专家委员会. 恶性肿瘤患者的营养治疗专家共识[J]. 临床肿瘤学杂志,2012,17(1):59-73. DOI:10.3969/j.issn.1009-0460.2012.01.013. CSCO expert committee on tumor nutrition therapy. Expert consensus on nutritional therapy for patients with malignant tumor[J]. J Clin Oncol,2012,17(1):59-73. DOI:10.3969/j.issn.1009-0460.2012.01.013. [14]Arends J,Bachmann P,Baracos V,et al. ESPEN guidelines on nutrition in cancer patients[J]. Clin Nut,2017,36(1):11-48. DOI:10.1016/j.clnu.2016.07.015. [15]Langius JAE,Kruizenga HM,Uitdehaag BMJ,et al. Resting energy expenditure in head and neck cancer patients before and during radiotherapy[J]. Clin Nut,2012,31(4):549-554. DOI:10.1016/j.clnu.2011.12.009. [16]García-Peris P,Lozano MA,Velasco C,et al. Prospective study of resting energy expenditure changes in head and neck cancer patients treated with chemoradiotherapy measured by indirect calorimetry[J]. Nutrition,2005,21(11-12):1107-12. DOI:10.1016/j.nut.2005.03.006. [17]Wada A,Sonoda C,Makino Y,et al. Effects of Parenteral amino acid administration on the postoperative nutritional status and wound healing of protein-malnourished rats[J]. J Nutr Sci Vitaminol (Tokyo),2018,64(1):34-40. DOI:10.3177/jnsv.64.34. [18]Medlin S. Nutrition for wound healing[J]. Br J Nurs,2012,21(12):S11-12,S14-15. DOI:10.12968/bjon.2012.21. Sup12. S11. [19]Demling RH. Nutrition,Anabolism,and the wound healing process:an overview[J]. Eplasty,2009,9:e9. [20]Anna L,Jacek Z,Magdalena D,et al. Fatty acid Profile and biological activities of linseed and rapeseed oils[J]. Molecules,2015,20(12):22872-80. DOI:10.3390/molecules201219887. [21]Kaur G,Guo XF,Sinclair AJ. Short update on docosapentaenoic acid:a bioactive long-chain n-3 fatty acid[J]. Curr Opin Clin Nutr Metab Care,2016,19(2):88-91. DOI:10.1097/MCO.0000000000000252. [22]Cipollina C,Salvatore SR,Muldoon MF,et al. Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives[J]. PLoS One,2014,9(4):e94836. DOI:10.1371/journal.pone.0094836.eCollection 2014. [23]Mir O,Coriat R,Blanchet B,et al. Sarcopenia predicts early dose-limiting toxicities and pharmacokinetics of sorafenib in patients with hepatocellular carcinoma[J]. PLoS One,2012,7(5):e37563. DOI:10.1371/journal.pone.0037563. [24]CarloU,Yasuhiro K. Recent advances in the chemical synthesis of N-linked glycoproteins[J]. Curr Opin Chem Biol,2018,V46N:130-137. DOI:10.1016/j.cbpa.2018.07.004. [25]Salgado RM,Cruzcastaeñeda O,Elizondovázquez F,et al. Maltodextrin/ascorbic acid stimulates wound closure by increasing collagen turnover and TGF-β1 expression in vitro and changing the stage of inflammation from chronic to acute in vivo[J]. J Tis Viab,2017,26(2):131-137. DOI:10.1016/j.jtv.2017.01.004. [26]Aoki S,Fujii M,Fujie T. The efficacy of basic fibroblast growth factor-loaded poly (lactic-co-glycolic acid) nanosheet for mouse wound healing[J]. Wound Rep Regener,2018,25(6):1008-1016. DOI:10.1111/wrr.12604. [27]Liu YH,Guo PF,Chen GY,et al. Advances in the research of effects of glutamine on immune function of burn patients[J]. Chin J Burns,2018,34(4):249-253. DOI:10.3760/cma.j.issn.1009-2587.2018.04.012. [28]Raizel R,Tirapegui J. Role of glutamine,as free or dipeptide form,on muscle recovery from resistance training:a review study[J]. Nutrire,2018,43(1):28. DOI:10.1186/s41110-018-0087-9. [29]Ruxia W,Hongchao J,Jingpeng Z,et al. L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a nitric oxide-dependent manner in C2C12 cells[J]. Oxid Med Cell Long,2018,2018:7569127. DOI:10.1155/2018/7569127.eCollection 2018. [30]Mccarthy MS,Martindale RG. Immunonutrition in critical illness:what is the role?[J]. Nut Clin Pract,2018,33(3):348-358. DOI:10.1002/ncp.10102. [31]Bin BH,Seo J,Kim ST. Function,structure,and transport aspects of ZIP and ZnT zinc transporters in immune cells[J]. J Immunol Res,2018,2018:9365747. DOI:10.1155/2018/9365747.eCollection 2018. [32]Lin PH,Sermersheim M,Li H,et al. Zinc in wound healing modulation[J]. Nutrients,2017,10(1). DOI:10.3390/nu10010016. [33]Sara N,Brock D,Robin C,et al. Poor vitamin status is associated with skeletal muscleloss and mucositis in head and neck cancer patients[J]. Nutrients,2018,10(9).pii:E1236. DOI:10.3390/nu10091236. [34]Pantet O,Stoecklin P,Charrière M,et al. Trace element repletion following severe burn injury:a dose-finding cohort study[J]. Clin Nutr,2019,38(1):246-251. DOI:10.1016/j.clnu.2018.01.025. [35]Rembe JD,Frommdornieden C,Stuermer EK. Effects of vitamin B complex and vitamin C on human skin cells:is the perceived effect measurable?[J]. Adv Skin Wound Care,2018,31(5):225-233. DOI:10.1097/01. ASW.0000531351.85866.d9. [36]Lobb R,Jacobson G,Cursons R,et al. The interaction of selenium with chemotherapy and radiation on normal and malignant human mononuclear blood cells[J]. Int J Mol Sci,2018,19(10).pii:E3167. DOI:10.3390/ijms19103167.
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