针对单次大剂量放疗的LQ及BED模型研究进展

doi:10.3760/cma.j.issn.1004-4221.2018.09.015

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Abstract The linear quadratic (LQ) model and deduced biological equivalent dose (BED) model are widely applied in the radiobiological studies and the mathematic models of radiation oncology in clinical practice. However, the LQ model cannot accurately fit the experimental and clinical data in the high-dose region under the high-dose-per-fraction treatment mode. To resolve this issue, researchers have made modifications to the LQ models since 2008. In the paper, first, the theoretical basis and the application scope of LQ and BED models were introduced and the debate on whether LQ model is applicable to the high-dose-per-fraction radiotherapy was reviewed. Second, five modified models were introduced in two categories and their characteristics were summarized. Finally, current research situation and existing problems of radiotherapy using biological equivalent dose (BED) models were briefly summarized and the development trend of models was predicted.

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	Zhu Jian
	Yue Chenxi
	Yin Yong
	Li Baosheng
	Yang Bo

Key words： Neoplasm stereotactic body radiotherapy Linear quadratic model Biological equivalent dose

Fund:National Natural Science Foundation Project of China (81671785);China Postdoctoral Science Foundation Project (2016T90412);Key Research and Development Program of Shandong Province (2017CXZC1206);Shandong Natural Science Foundation Project (2016ZRC03118)

Corresponding Authors: Yang Bo, Email:yangbo@ujn.edu.cn

Cite this article:

Zhu Jian,Yue Chenxi,Yin Yong et al. Research progress on linear quadratic and biological equivalent dose models for high-dose-per-fraction radiotherapy[J]. Chinese Journal of Radiation Oncology, 2018, 27(9): 859-863.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.09.015 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I9/859

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