早期原发鼻腔NK/T细胞淋巴瘤局部扩大野IMRT前瞻性Ⅱ期研究的初步结果

doi:10.3760/cma.j.issn.1004-4221.2015.04.006

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Abstract Objective To investigate the feasibility of the scheme of target volume delineation with extended involved-field intensity-modulated radiotherapy (IMRT) for patients with early-stage nasal NK/T-cell lymphoma (NC-NKTL). Methods Twenty-one patients with stage I_{E-II_E NC-NKTL were treated with short-course chemotherapy combined with radiotherapy from 2011 to 2013. The majority of patients received the GELOX regimen. All patients received extended involved-field IMRT with a dose of 54.6 Gy in 26 fractions for gross tumor volume, 50.7 Gy in 26 fractions for high-risk clinical target volume (CTV), and 45.5 Gy in 26 fractions for low-risk CTV. The dose distribution, short-term treatment outcomes, and adverse reactions were analyzed. Results The 2-year sample size was 12. The 2-year follow-up rate was 100%. The 2-year local control rate (LRC) was 100%. The 2-year overall and progression-free survival rates were 90.5% and 90.5%, respectively. The median coverage rates of planning target volumes with 90% of the prescribed doses of 54.6 Gy, 50.7 Gy, and 45.5 Gy were 99.8%, 99.6%, and 99.7%, respectively. No grade 3 or 4 adverse reactions were observed in patients. Conclusions The scheme of target volume delineation and dose configuration in our study not only achieves excellent target volume coverage, but also reduces adverse reactions in patients, which achieves a 2-year LRC ideal for patients with early-stage NC-NKTL.}

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	Articles by authors
	Niu Shaoqing^*
	Zhang Yujing
	Wen Ge
	Li Yiyang
	Feng Lingling
	Wang Hanyu
	Wen Bixiu

Key words： Extranodal Natural Killer/T-cell lymphoma, nasal type/intensity-modulated radiotherapy Extended involved-field Curative effect

Received: 08 September 2014

Corresponding Authors: Zhang Yujing,Email:zhangyj@sysucc.org.cn

Cite this article:

Niu Shaoqing^*,Zhang Yujing,Wen Ge et al. Preliminary results of a phase Ⅱ prospective clinical study of early-stage nasal NK/T-cell lymphoma with extended involved-field intensity-modulated radiotherapy[J]. Chinese Journal of Radiation Oncology, 2015, 24(4): 377-381.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2015.04.006 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2015/V24/I4/377

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