前列腺癌多目标优化VMAT计划剂量学研究

doi:10.3760/cma.j.issn.1004-4221.2015.01.022

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摘要目的探讨多目标优化在前列腺癌VMAT计划中的应用。方法随机抽取已接受治疗的14例前列腺癌患者VMAT计划资料。这些计划基于单目标优化,保持优化条件不变,改用多目标优化。配对t检验两种计划剂量学参数差异。结果两种计划均满足临床要求,与单目标计划相比,多目标计划PTV 95%、100%处方剂量覆盖度增加(P=0.000、0.000),105%处方剂量覆盖度降低(P=0.000),D_max降低0.35 Gy (P=0.063);直肠V₂₀、V₃₀、V₄₀、V₅₀和D_mean分别降低24.7%、36.8%、31.1%、20.5%和6.8 Gy (P=0.000、0.000、0.000、0.001、0.000),D₂cc增加1.4 Gy (P=0.000);膀胱V₁₀、V₂₀、V₃₀、V₄₀、V₅₀和D_mean分别降低5.7%、18.5%、20.9%、12.5%、5.4%和3.5 Gy (P=0.006、0.000、0.000、0.000、0.002、0.000);小肠V₁₀、V₂₀、V₃₀和D_mean多目标计划有优势。结论多目标计划在满足靶区剂量情况下可以进一步降低OAR剂量,但结果还需进一步研究和评估。

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	作者相关文章
	王昊
	邱杰
	全红
	杨波
	庞廷田
	刘峡
	刘楠
	张福泉

关键词 ：前列腺肿瘤/容积调强弧形疗法, 多目标优化, 剂量学

Abstract：Objective The aim of this study is to evaluate the multicriteria optimization (MCO) in planning volumetric modulated arc therapy (VMAT) for prostate cancer. Methods 14 prostate patients VMAT plans with single criteria optimization,while keeping optimization conditions,new plans were thenoptimized with MCO,dosimetry parameters comparison were made between both kinds of plans. ResultsTwo kinds of VMAT plans satisfied clinical requirements. To compare with SCO plans,PTV 95% and PTV 100% prescription dose coverage of MCO plans increased (P=0.000,0.000),PTV 105% dose coverage became lower (P=0.000),D_max decreased 0.35 Gy (P=0.063).V₂₀,V₃₀,V₄₀,V₅₀ and D_mean of the rectum were reduced by about 24.7%,36.8%,31.1%,20.5% and 6.8 Gy respectively (P=0.000,0.000,0.000,0.001,0.000),D₂cc increased 1.4 Gy (P=0.000);V₁₀,V₂₀,V₃₀,V₄₀,V₅₀ and D_mean of the bladder were reduced by about 5.7%,18.5%,20.9%,12.5%,5.4% and 3.5 Gy respectively (P=0.006,0.000,0.000,0.000,0.002,0.000);V₁₀,V₂₀,V₃₀ and D_mean of small intestine were better in MCO plans. Conclusions MCO plans could reduce the dose of organs at risk while PTV dose prescription satisfied,but the result needs further research and evalution.

Key words： Prostate neoplasms/volumetric modulated arc therapy Multicriteria optimization Dosimetry

收稿日期: 2013-09-30

通讯作者: 邱杰,Email: qjww@sina.com

引用本文:

王昊,邱杰,全红等. 前列腺癌多目标优化VMAT计划剂量学研究[J]. 中华放射肿瘤学杂志, 2015, 24(1): 82-88.

Wang Hao,Qiu Jie,Quan Hong et al. Dosimetric study of multicriteria optimization volumetric modulated arc therapy (VMAT) planning for prostate cancer[J]. Chinese Journal of Radiation Oncology, 2015, 24(1): 82-88.

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http://journal12.magtechjournal.com/Jweb_fszlx/CN/10.3760/cma.j.issn.1004-4221.2015.01.022 或 http://journal12.magtechjournal.com/Jweb_fszlx/CN/Y2015/V24/I1/82

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