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头颈部恶性肿瘤嗜神经侵袭临床诊治现状
王泽坤, 罗京伟
国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021
Clinical diagnosis and treatment of perineural invasion of head and neck malignant tumors
Wang Zekun, Luo Jingwei
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021,China
Abstract：Perineural invasion is a unique biological behavior of tumors via nerve dissemination and metastasis,which is intimately correlated with the recurrence,metastasis and prognosis. With the deepening research, the clinical significance of perineural invasion has been widely recognized. However,due to the low incidence of head and neck neoplasms and the varying incidence of perineural invasion in different anatomical sites and pathological types,high-level evidence-based medical evidence is still lacking. Currently,the pathological mechanism of perineural invasion has not been clearly clarified. No specific treatment has been available for perineural invasion. Therefore,the treatment of perineural invasion of head and neck tumors is an enormous challenge for clinicians. In this article, the current status of clinical diagnosis and treatment of perineural invasion in head and neck malignancies was reviewed.
Wang Zekun,Luo Jingwei. Clinical diagnosis and treatment of perineural invasion of head and neck malignant tumors[J]. Chinese Journal of Radiation Oncology, 2020, 29(2): 146-149.
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2020, Vol. 29 
