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食管癌术后辅助治疗的研究进展
倪文婕, 肖泽芬
国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021
Research progress on postoperative adjuvant therapy for esophageal carcinoma
Ni Wenjie, Xiao Zefen
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021,China
Abstract：In China,radical esophagectomy remains the main strategy for resectable esophageal cancer. However,the high locoregional recurrence rate and hematogenous metastasis rate are the main causes of surgical failure. Therefore,whether postoperative adjuvant therapy can become one of the important means for esophageal cancer remains controversial. In this article, the research progress on the postoperative recurrent pattern and adjuvant therapy for esophageal carcinoma was reviewed to provide references for clinicians.
Ni Wenjie,Xiao Zefen. Research progress on postoperative adjuvant therapy for esophageal carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(12): 945-948.
[1]Lu J,Tao H,Song D,et al. Recurrence risk model for esophageal cancer after radical surgery[J]. Chin J Cancer Res,2013,25(5):549-555. DOI:10.3978/j.issn.1000-9604.2013.10.05. [2]Miyata H,Yamasaki M,Kurokawa Y,et al. Survival factors in patients with recurrence after curative resection of esophageal squamous cell carcinomas[J]. Ann Surg Oncol,2011,18(12):3353-3361. DOI:10.1245/s10434-011-1747-7. [3]Oppedijk V,van der Gaast A,van Lanschot JJB,et al. Patterns of recurrence after surgery alone versus preoperative chemoradiotherapy and surgery in the CROSS trials[J]. J Clin Oncol,2014,32(5):385-391. DOI:10.1200/JCO.2013.51.2186. [4]Liu Q,Cai XW,Wu B,et al. Patterns of failure after radical surgery among patients with thoracic esophageal squamous cell carcinoma:implications for the clinical target volume design of postoperative radiotherapy[J/OL]. PLoS One,2014,9(5):e97225. DOI:10.1371/journal.pone.0097225. [5]Hsu P,Wang B,Huang C,et al. Prognostic factors for post-recurrence survival in esophageal squamous cell carcinoma patients with recurrence after resection[J]. J Gastrointestinal Surg,2011,15(4):558-565. DOI:10.1007/s11605-011-1458-1. [6]Li CL,Zhang FL,Wang YD,et al. Characteristics of recurrence after radical esophagectomy with two-field lymph node dissection for thoracic esophageal cancer[J]. Oncol Lett,2013,5(1):355-359. DOI:10.3892/ol.2012.946. [7]Su XD,Zhang DK,Zhang X,et al. Prognostic factors in patients with recurrence after complete resection of esophageal squamous cell carcinoma[J]. J Thorac Dis,2014,6(7):949-957. DOI:10.3978/j.issn.2072-1439.2014.07.14. [8]Guo XF,Mao T,Gu Z T,et al. Clinical study on postoperative recurrence in patients with pN0 esophageal squamous cell carcinoma[J]. J Cardiothorac Surg,2014,9:150. DOI:10.1186/s13019-014-0150-4. [9]Blom RL,Lagarde SM,van Oudenaarde K,et al. Survival after recurrent esophageal carcinoma has not improved over the past 18 years[J]. Ann Surg Oncol,2013,20(8):2693-2698. DOI:10.1245/s10434-013-2936-3. [10]刘晓,章文成,于舒飞,等. T2-3N0M0期食管癌R0术后失败模式分析——术后放疗潜在价值与意义[J]. 中华放射肿瘤学杂志,2015,24(1):19-24. DOI:10.3760/cma.j.issn.1004-4221.2015.01.006. Liu X,Zhang WC,Yu SF,et al. Failure mode analysis of R0 operation for stage T2-3N0M0 esophageal cancer:potential value and significance of postoperative radiotherapy[J]. Chin J Radiat Oncol,2015,24(1):19-24. DOI:10.3760/cma.j.issn.1004-4221.2015.01.006. [11]王玉祥,杨琼,何明,等.Ⅲ期胸段食管鳞癌根治术后的复发规律[J]. 中华肿瘤杂志,2017,39(1):48-55. DOI:10.3760/cma.j.issn.0253-3766.2017.01.010. Wang YX,Yang Q,He M,et al. Recurrence regularity of stage Ⅲ thoracic esophageal squamous cell carcinoma after radical resection[J]. Chin J Oncol,2017,39(1):48-55. DOI:10.3760/cma.j.issn.0253-3766.2017.01.010. [12]Pouliquen X,Levard H,Hay JM,et al.5-Fluorouracil and cisplatin therapy after palliative surgical resection of squamous cell carcinoma of the esophagus. A multicenter randomized trial. French Associations for Surgical Research[J]. Ann Surg,1996,223(2):127-133. [13]Ando N,Iizuka T,Kakegawa T,et al. A randomized trial of surgery with and without chemotherapy for localized squamous carcinoma of the thoracic esophagus:the Japan Clinical Oncology Group Study[J]. J Thorac Cardiovasc Surg,1997,114(2):205-209. DOI:10.1016/S0022-5223(97)70146-6. [14]Ando N,Iizuka T,Ide H,et al. Surgery plus chemotherapy compared with surgery alone for localized squamous cell carcinoma of the thoracic esophagus:a Japan Clinical Oncology Group Study—JCOG9204[J]. J Clin Oncol,2003,21(24):4592-4596. DOI:10.1200/JCO.2003.12.095. [15]Macdonald JS,Smalley SR,Benedetti J,et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction[J]. N Engl J Med,2001,345(10):725-730. DOI:10.1056/NEJMoa010187. [16]Smalley SR,Benedetti JK,Haller DG,et al. Updated analysis of SWOG-directed intergroup study 0116:a phase Ⅲ trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection[J]. J Clin Oncol, 2012,30(19):2327-2333. DOI:10.1200/JCO.2011.36.7136. [17]Bedard EL,Inculet RI,Malthaner RA,et al. The role of surgery and postoperative chemoradiation therapy in patients with lymph node positive esophageal carcinoma[J]. Cancer,2001,91(12):2423-2430. [18]Rice TW,Adelstein DJ,Chidel MA,et al. Benefit of postoperative adjuvant chemoradiotherapy in locoregionally advanced esophageal carcinoma[J]. J Thorac Cardiovas Surg,2003,126(5):1590-1596. DOI:10.1016/S0022-5223(03)01025-0. [19]Kofoed SC,Muhic A,Baeksgaard L,et al. Survival after adjuvant chemoradiotherapy or surgery alone in resectable adenocarcinoma at the gastro-esophageal junction[J]. Scand J Surg,2012,101(1):26-31. DOI:10.1177/145749691210100106. [20]Goodner JT. Surgical and radiation treatment of cancer of the thoracic esophagus[J]. Am J Roentgenol Radium Ther Nucl Med,1969,105(3):523-528. [21]Kunath U,Fischer P. Radical nature and life expectancy in the surgical treatment of esophageal and cardial carcinoma[J]. Dtsch Med Wochenschr,1984,109(12):450-453. DOI:10.1055/s-2008-1069212. [22]Teniere P,Hay JM,Fingerhut A,et al. Postoperative radiation therapy does not increase survival after curative resection for squamous cell carcinoma of the middle and lower esophagus as shown by a multicenter controlled trial. French University Association for Surgical Research[J]. Surg Gynecol Obstet,1991,173(2):123-130. [23]Fok M,Sham JS,Choy D,et al. Postoperative radiotherapy for carcinoma of the esophagus:a prospective,randomized controlled study[J]. Surgery,1993,113(2):138-147. [24]Zieren HU,Muller JM,Jacobi CA,et al. Adjuvant postoperative radiation therapy after curative resection of squamous cell carcinoma of the thoracic esophagus:a prospective randomized study[J]. World J Surg,1995,19(3):444-449. [25]Xiao ZF,Yang ZY,Liang J,et al. Value of radiotherapy after radical surgery for esophageal carcinoma:a report of 495 patients[J]. Ann Thorac Surg,2003,75(2):331-336. DOI:10.1016/S0003-4975(02)04401-6. [26]Xiao Z,Yang Z,Miao Y,et al. Influence of number of metastatic lymph nodes on survival of curative resected thoracic esophageal cancer patients and value of radiotherapy:Report of 549 cases[J]. Int J Radiat Oncol Biol Phys,2005,62(1):82-90. DOI:10.1016/j.ijrobp.2004.08.046. [27]Schreiber D,Rineer J,Vongtama D,et al. Impact of postoperative radiation after esophagectomy for esophageal cancer[J]. J Thorac Oncol,2010,5(2):244-250. DOI:10.1097/JTO.0b013e3181c5e34f. [28]Chen J,Pan J,Zheng X,et al. Number and location of positive nodes,postoperative radiotherapy,and survival after esophagectomy with three-field lymph node dissection for thoracic esophageal squamous cell carcinoma[J]. Int J Radiat Oncol Biol Phys,2012,82(1):475-482. DOI:10.1016/j.ijrobp.2010.08.037. [29]Xu Y,Liu J,Du X,et al. Prognostic impact of postoperative radiation in patients undergoing radical esophagectomy for pathologic lymph node positive esophageal cancer[J]. Radiat Oncol,2013,8:116. DOI:10.1186/1748-717X-8-116. [30]Worni M,Martin J,Gloor B,et al. Does surgery improve outcomes for esophageal squamous cell carcinoma? An analysis using the surveillance epidemiology and end results registry from 1998 to 2008[J]. J Am Coll Surg,2012,215(5):643-651. DOI:10.1016/j.jamcollsurg.2012.07.006. [31]Shridhar R,Weber J,Hoffe SE,et al. Adjuvant radiation therapy and lymphadenectomy in esophageal cancer:a SEER database analysis[J]. J Gastrointest Surg,2013,17(8):1339-1345. DOI:10.1007/s11605-013-2192-7. [32]Dresner SM,Griffin SM. Pattern of recurrence following radical oesophagectomy with two-field lymphadenectomy[J]. Br J Surg,2000,87(10):1426-1433. DOI:10.1046/j.1365-2168.2000.01541.x. [33]Mariette C,Balon JM,Piessen G,et al. Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease[J]. Cancer,2003,97(7):1616-1623. DOI:10.1002/cncr.11228. [34]Rice TW,Rusch VW,Apperson-Hansen C,et al. Worldwide esophageal cancer collaboration[J]. Dis Esophag,2009,22(1):1-8. DOI:10.1111/j.1442-2050.2008.00901.x. [35]Situ D,Wei W,Lin P,et al. Do Tumor grade and location affect survival in esophageal squamous cell carcinoma? Survival analysis of 302 cases of pT3N0M0 esophageal squamous cell carcinoma[J]. Ann Surg Oncol,2013,20(2):580-585. DOI:10.1245/s10434-012-2656-0. [36]Visbal AL,Allen MS,Miller DL,et al. Ivor Lewis esophagogastrectomy for esophageal cancer.[J]. Ann Thorac Surg,2001,71(6):1803-1808. DOI:10.1016/S0003-4975(01)02601-7. [37]Chen J,Zhu J,Pan J,et al. Postoperative radiotherapy improved survival of poor prognostic squamous cell carcinoma esophagus[J]. Ann Thorac Surg,2010,90(2):435-442. DOI:10.1016/j.athoracsur.2010.04.002. [38]Yang J,Zhang W,Xiao Z,et al. The Impact of postoperative conformal radiotherapy after radical surgery on survival and recurrence in pathologic T3N0M0 esophageal carcinoma:a propensity score-matched analysis[J]. J Thorac Oncol,2017,12(7):1143-1151. DOI:10.1016/j.jtho.2017.03.024. [39]Deng W,Yang J,Xiao Z,et al. Postoperative radiation therapy in pathologic T2-3N0M0 thoracic esophageal squamous cell carcinoma:interim report of a prospective,phase 3,randomized controlled study[J]. Int J Radiat Oncol Biol Phys,2017,99(2):S190-S191. [40]Zhang W,Liu X,Xiao Z,et al. Postoperative intensity-modulated radiotherapy improved survival in lymph node-positive or stage Ⅲ trhoracic esophageal squamous cell carcinoma[J]. Oncol Res Treat,2015,38(3):97-102. DOI:10.1159/000375391. [41]Yeh H,Hsu C,Lin J,et al. A retrospective study of postoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma[J]. Form J Surg,2012,45(6):172-177. DOI:10.1016/j.fjs.2012.10.001. [42]Hsu P,Huang C,Wang B,et al. Survival benefits of postoperative chemoradiation for lymph node-positive esophageal squamous cell carcinoma[J]. Ann Thorac Surg,2014,97(5):1734-1741. DOI:10.1016/j.athoracsur.2013.12.041. [43]Chen J,Pan J,Liu J,et al. Postoperative radiation therapy with or without concurrent chemotherapy for node-positive thoracic esophageal squamous cell carcinoma[J]. Int J Radiat Oncol Biol Phys,2013,86(4):671-677. DOI:10.1016/j.ijrobp.2013.03.026. [44]Wong AT,Shao M,Rineer J,et al. The impact of adjuvant postoperative radiation therapy and chemotherapy on survival after esophagectomy for esophageal carcinoma[J]. Ann Surg,2017,265(6):1146-1151. DOI:10.1097/SLA.0000000000001825.
2019, Vol. 28 
